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吡格列酮对糖尿病大鼠中枢神经系统11β-羟类固醇脱氢酶1 型表达的影响
綦雯雯贾凯英孙达富晶杨敏潘磊
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摘要:
目的研究吡格列酮对糖尿病大鼠海马、下丘脑处11β-羟类固醇脱氢酶1 型(11β-HSD1) 表达的影响及与认知功能的关系。方法雄性SD 大鼠随机分为对照组(C 组)、糖尿病组(D 组)、糖尿病+ 吡格列酮治疗组(DP 组),每组10 只。8 周后行Morris 水迷宫评价大鼠的认知功能,Western Blot 方法检测大鼠海马、下丘脑处11β-HSD1 表达水平。结果Morris 水迷宫中,D 组大鼠穿越原平台区次数较C 组减少,DP 组大鼠较D 组增多,差异有统计学意义(P <0.01)。在海马和下丘脑处,11β-HSD1 表达D 组较C 组增加,DP 组较D 组减少,较C 组增加,差异有统计学意义(P <0.01)。结论吡格列酮能够降低糖尿病大鼠海马、下丘脑组织局部11β-HSD1 表达水平,并且可能是吡格列酮改善糖尿病大鼠空间学习记忆能力的机制之一。
关键词:  糖尿病  中枢神经系统  11β-HSD1  认知功能  吡格列酮
DOI:10.3969/j.issn.1009-6574.2017.03.009
基金项目:
Effects of pioglitazone on expressions of 11β-hydroxysteroid dehydrogenase type 1 in central ner-vous system of diabetic rats
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Abstract:
Objective To study the effects of pioglitazone (PGZ) on the expressions of 11β-hydroxys-teroid dehydrogenase type 1(11β-HSD1) in central nervous system of diabetic rats and its asociation with cog-nitive function. Methods Thirty male SD rats were equally randomized into Control group (C group),Diabetic group (D group) and Diabetes+Pioglitazone group (DP group). Morris-water maze was used to test the cognitive function after 8 weeks. Western Blot was used to detect the expressions of 11β-HSD1 in hippocampus and hy-pothalamus. Results In Morris water maze,the number of crossing the platform in D group were significantly less than C group and DP group (P <0.01). The 11β-HSD1 expressions in hippocampus and hypothalamus of D group were significantly increased than C group and DP group,while the 11β-HSD1 expressions of DP group were significantly increased than C group (P <0.01). Conclusion Pioglitazone may improve cognitive function in diabetic rats,partly through the decrease of 11β-HSD1 expressions in hippocampus and hypothalamus.
Key words:  Diabetes mellitus  Central nervous system  11β-HSD1  Cognitive function  Piogli-tazone

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