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中国抽动障碍患者生活质量及影响因素的循证评价
肖林杨静黄亮俞丹杨春松
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摘要:
目的 系统评价中国抽动障碍(TD)患者生活质量现状,为改善TD生活质量提供循证医学 证据。方法 检索Pubmed,Embase,Cochrane library, CBM,CNKI,VIP和万方数据库,检索时间为建库 至2017年6月,纳入评价TD患者生活质量的文献,对研究结果进行描述性分析。结果 纳入9篇文献, 涉及1 273例TD患者,年龄8~16岁,发表时间2002~2016年。7项研究采用不同的ISLQ分析,发现TD患 者生活质量低于健康对照组,仅3项研究分析了TD的影响因素。结论 中国TD患者生活质量不高,低 于健康对照组。但研究样本量不高,采用的不同评价量表,较少研究分析相关影响因素。建议未来研究 中开展大样本、多中心的研究,进一步探索TD患者生活质量和影响因素。
关键词:  抽动障碍  生活质量  影响因素  循证评价
DOI:10.3969/j.issn.1009-6574.2017.10.002
基金项目:国家自然科学基金面上项目(81373381)
Evidence-based assessment of life quality and its influencing factors in tic disorder patients in China
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Abstract:
Objective To systematically review the current status of life quality in patients with tic disorder( TD) in China, so as to provide evidence for improving life quality of TD. Methods We searched Pubmed, Embase, Cochrane library, China Biology Medicine disc( CBMdisc), CNKI, VIP and Wanfang databases from inception to June 2017. Studies which assessed the life quality of TD were included, and then descriptive analysis were used to summarized the results. Results A total of 9 studies published from 2002 to 2016, involving 1 273 patients aged from 8 to 16 years old, were included. Seven studies found that the TD patients’ life quality was lower than the healthy control group by using different inventory of subjective life quality( ISLQ) scales. However only 3 studies analyzed the influencing factors of the life quality of TD. Conclusions TD’ life quality in China is low, compared with the control group. However, the sample sizes are small, different evaluation scales are adopted, and there is lack of analysis of related influencing factors. It is recommended to carry out large sample and multicenter research for further exploration of the quality of life of TD patients and its influencing factors.
Key words:  Tic disorder  Quality of life  Influencing factor  Evidence-based assessment

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