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盐酸美金刚对阿尔茨海默病患者血清S100B和抗脑抗体的影响
黄隽超兰志敏尚兰张建新王志仁陈松李佳杨甫德谭云龙
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摘要:
目的 分析盐酸美金刚对阿尔茨海默病(AD)患者的疗效及对血清S100B、抗脑抗体(ABAb) 浓度的影响,探讨S100B、ABAb在AD疾病进展中可能的作用。方法 共纳入AD患者32例(AD组),采用 盐酸美金刚(10~20 mg/d)治疗,治疗周期6个月,分别于治疗基线、3个月、6个月进行访视;同期纳入无认 知障碍老年对照40名(对照组)。采用简易精神状况检查表(MMSE)、日常生活活动量表(ADL)评估所有研 究对象认知功能和生活能力,采用AD评定量表-认知(ADAS-Cog)进一步评定AD患者的认知功能;应用 酶联免疫吸附法(ELISA)检测血清S100B、ABAb浓度。结果 与对照组比较,AD患者血清S100B、ABAb 浓度显著升高(P<0.01)。经重复测量方差分析,AD患者治疗基线、3个月、6个月间S100B[ (0.66±0.17), (0.58±0.18),(0.50±0.14)μg/L;F=35.22,P< 0.01]和ABAb浓度[(1.93±0.95),(1.65±0.81),(1.30±0.70)U/L; F=42.93,P < 0.01]差异均有统计学意义;而MMSE、ADAS-Cog总分和ADL评分差异无统计学意义。 结论 盐酸美金刚可能通过降低中重度AD患者S100B、ABAb水平影响疾病的进程。
关键词:  阿尔茨海默病  盐酸美金刚  S100B蛋白  抗脑抗体
DOI:10.3969/j.issn.1009-6574.2017.10.006
基金项目:北京市医管局“登峰”人才培养计划(DFL20151901)
Effects of memantine hydrochloride on serum S100B protein and anti-brain anti-body levels in patientswith Alzheimer disease
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Abstract:
Objective To analyze the effects of memantine hydrochloride on the Alzheimer disease (AD) patients, the serum S100B protein and the anti-brain anti-body(ABAb) levels, and to discuss the possible effect of S100B and ABAb on the progression of AD. Methods In this study, 32 AD patients( AD group) and 40 volunteers without cognitive impairment( control group) were enrolled. AD patients received treatment of memantine hydrochloride( dose: 10-20mg/d) for 6 months, and were interviewed at the baseline,the 3rd and the 6th month from the beginning of the treatment. The cognitive function and living ability were assessed with Mini- Mental State Examination( MMSE) and Activity of Daily Living scale( ADL). The cognitive function of patients was further evaluated with Alzheimer Disease Assessment Scale Cognitive Sub-scale( ADAS-Cog). The serum S100B and ABAb levels were examined by enzyme linked immunosorbent assay( ELISA). Results The S100B and ABAb levels of AD patients were markedly increased compared with the control group( P<0.01). Analysis of variance of repeated measures indicated that there were significant differences in the serum S100B[ (0.66±0.17), (0.58±0.18),( 0.50±0.14)μg/L;F=35.22,P<0.01] and ABAb levels[ (1.93±0.95),( 1.65±0.81),( 1.30± 0.70)U/L;F=42.93,P< 0.01]among the baseline and the visit points of 3rd and 6th month after the beginning of the treatment, however, there was no significant difference in the scores of the MMSE, ADL and ADAS-Cog. Conclusions Memantine hydrochloride might effect on the progression of patients with moderate and severe AD by decreasing the S100B protein and ABAb levels.
Key words:  Alzheimer disease  Memantine hydrochloride  S100B protein  Anti-brain anti-body

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