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奥卡西平与碳酸锂治疗躁狂症对照研究:国内文献的 Meta 分析
金锐沈莹朱建峰高芝涵孙峰俐陈正昕任志斌李冰凌金卫东
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摘要:
目的 评价分析奥卡西平与碳酸锂治疗躁狂症的疗效差异。方法 通过数据检索,对10项奥 卡西平与碳酸锂治疗躁狂症的研究资料进行Meta分析,评价有效率的差异和症状改善的差异。结果 在 有效率方面,奥卡西平与碳酸锂治疗躁狂症的有效率差异无统计学意义(Z=0.10,P=0.92)。在症状学评 价方面,奥卡西平与碳酸锂治疗躁狂症的症状评分差异无统计学意义(Z=0.26,P=0.79)。结论 奥卡西 平与碳酸锂治疗躁狂症的疗效相似。
关键词:  奥卡西平  碳酸锂  躁狂症  Meta分析
DOI:10.3969/j.issn.1009-6574.2017.10.014
基金项目:
Domestic meta-analysis of the control studies on the treatment of mania by oxcarbazepine and lithiumcarbonate
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Abstract:
Objective To analyze the difference of curative effect between oxcarbazepine and lithium carbonate in treating manic episode. Methods The differences of effective rate and symptom improvement were assessed by retrieving database, and a total of 10 items of research data about manic treatment with oxcarbazepine and lithium carbonate were analyzed. Results Through heterogeneity test( χ2=1.89, df=9, P=0.98, I2=0%), by using the fixed effect model( WMD=1.02, 95%CI=0.72-1.45,Z=0.10, P=0.92), it suggested that there was no significant difference in the effective rate of oxcarbazepine and lithium carbonate in the treatment of mania. Through heterogeneity test( χ2=177.15, df=32, P < 0.01,I2=81.9%), by using random effect model( WMD= -0.03, 95%CI=-0.25-0.19,Z=0.26,P=0.79), it suggested that there was no significant difference in symptom score of treating mania with oxcarbazepine and lithium carbonate. Conclusions The effect of oxcarbazepine and lithium carbonate may be similar in the treatment of mania.
Key words:  Oxcarbazepine  Lithium carbonate  Mania  Meta-analysis

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