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事件相关电位P300与抑郁症严重程度的关系
张振清张晓阳吴娓娓
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摘要:
目的 探讨事件相关电位P300与抑郁症严重程度之间的关系。方法 对28例中度抑郁症 患者、41例重度抑郁患者与70例健康对照的P300行对照研究。结果 抑郁症患者P3潜伏期与HAMD 评分呈正相关(r=0.514,P < 0.01);中、重度抑郁组较健康对照组 N2、P3潜伏期延长,P3波幅降低,差 异均有统计学意义(P < 0.05);重度抑郁组较中度抑郁组P3潜伏期延长,差异有统计学意义(P=0.017)。 结论 抑郁症的认知功能损害与严重程度有关,P3潜伏期可能是抑郁症严重程度的预测性指标。
关键词:  抑郁症  认知  事件相关电位  严重程度
DOI:10.3969/j.issn.1009-6574.2017.12.011
基金项目:厦门市科学技术局科技计划项目(3502Z20154062); 福建省卫生计生委青年科研课题(2015-2-53)
Relationship between event-related potentials P300 and the severity of depression
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Abstract:
Objective To explore the relationship between event-related potentials P300 and the severity of depression. Methods A control study was conducted among 28 moderate depression patients, 41 severe depression patients and 70 healthy controls. Results The latency of P3 was positively correlated with the scores of Hamilton Depression Scale( HAMD-17)( r=0.514,P<0.01). Compared with the healthy control group, the moderate group and severe group showed prolonged latencies of N2 and P3, and decreased P3 amplitude, with statistical significance( P < 0.05). Compared with moderate group, the severe group showed prolonged P3 latency( P=0.017). Conclusions The cognitive impairment might be associated with the severity of the depression, and the P3 latency might be used as an indicator of severity in depression.
Key words:  Depression  Cognition  Event-related potentials  Severity

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