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癫痫共患双相情感障碍的影响因素分析
陈旭周娇娇王雪王巍巍罗炯
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摘要:
目的 比较癫痫共患双相情感障碍患者与共患其他精神障碍的临床特征,为临床早期识 别和规范治疗癫痫共患双相情感障碍提供依据。方法 本研究为回顾性研究,对2014—2017 年在北京 安定医院住院的所有诊断癫痫共患双相情感障碍或癫痫共患其他精神障碍患者进行临床特征调查,采 用自行编制的信息调查表对患者病历资料进行整理分析。结果 癫痫共患双相情感障碍与癫痫共患其 他精神障碍受试者在受教育年限、首次发作年龄、是否伴高热、有无其他诱因、首次诊断癫痫年龄、发 作类型、发作频率、是否手术治疗、癫痫控制是否理想以及IQ 分值方面差异均有统计学意义(χ2=8.495、 4.455、5.343、53.828、6.313、53.828、17.697、59.889、6.313、8.495,P均< 0.05)。多因素Logistic 回归模型 分析显示,首次发作年龄(OR=1.537,P=0.011)、癫痫控制是否理想(OR=1.595,P=0.028)与是否共患双相 情感障碍相关。结论 癫痫共患双相情感障碍患者起病年龄较晚,癫痫治疗较理想,早期识别其共患 双相情感障碍对癫痫预后有益。
关键词:  癫痫  双相情感障碍  影响因素
DOI:10.3969/j.issn.1009-6574.2018.11.004
基金项目::国家重点研发计划(2016YFC1307200);北京市医院管理局临床医学发展专项经费资助 (ZYLX201607);北京市医院管理局“登峰”计划专项经费资助(DFL20151801)
An analysis of affecting factors for epileptic comorbid bipolar disorder
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Abstract:
Objective To compare the clinical features of patients with epileptic comorbid bipolar disorder and with other mental disorders, so as to provide evidence for early identification and standard treatment in clinical practice for epilepsy comorbid with bipolar disorder. Methods This study was a retrospective study. All patients who were diagnosed as epileptic comorbid bipolar disorder and epilepsy comorbid with other mental disorders in Beijing Anding Hospital were investigated for clinical from 2014 to 2017. The data of patients' medical records were collated and analyzed by self-compiled information questionnaire. Results The differences between patients with epileptic comorbid bipolar disorder and with other mental disorders in education background, age of first episode, whether with high fever, with or without other causes, first diagnosis age of epilepsy, type of seizure, frequency of seizures, whether with the surgical treatment, ideal epilepsy control and IQ scores were statistically significant( χ2=8.495,4.455,5.343,53.828,6.313,53.828, 17.697,59.889,6.313,8.495;P < 0.05). Multivariate Logistic regression model analysis showed that age of first episode( OR=1.537,P=0.011), ideal epilepsy control( OR=1.595,P=0.028) were associated with bipolar disorder. Conclusions Patients with epileptic comorbid bipolar disorder have an older age of onset. Ideal epilepsy treatment and early recognition of bipolar disorder are beneficial to the prognosis.
Key words:  Epilepsy  Bipolar disorder  Influencing factors

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