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首发抑郁症患者静息态MRI脑局部一致性的改变
孙洪言刘海花顾苗苗王蕾张渊
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摘要:
目的 利用静息态MRI 技术去探索首发抑郁症患者特异脑区的脑功能改变。方法 对符 合抑郁症诊断标准的20 例患者及20 名健康志愿者进行静息态MRI检查,使用静息态MRI局部一致性 (ReHo)分析方法,比较抑郁症组与对照组ReHo 值,发现特异性增高或减低的脑区。结果 抑郁症组 对比对照组,ReHo 增高的脑区有小脑后叶、颞下回、枕中回、舌回、中央后回、中央前回、额上回、顶 叶等;ReHo 降低的脑区有边缘叶、海马旁回、壳核、丘脑、豆状核、额下回、额中回、楔前叶、扣带回等。 结论 静息态MRI 的ReHo 分析方法可能发现抑郁症异常的脑区,为抑郁症发病机制的探索提供帮助。
关键词:  抑郁症  磁共振成像,静息态  局部一致性
DOI:10.3969/j.issn.1009-6574.2018.11.007
基金项目:苏州市“科教兴卫”青年科技项目(KJXW2017048)
Study on the regional homogeneity of resting brain MRI in first-episode depression
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Abstract:
Objective To explore the changes of brain function in the specific brain regions of firstepisode depressive patients using resting state magnetic resonance imaging( MRI) technology. Methods Resting state MRI examination was performed on 20 patients who met the diagnostic criteria of depression and 20 healthy volunteers. The resting state MRI regional homogeneity( ReHo) was used to compare the ReHo values of the depression group, to find brain regions with increased or reduced specificity. Results Compared with the control group, the brain areas with increased ReHo were posterior cerebellar lobe, inferior temporal gyrus, middle occipital gyrus, lingual gyrus, posterior central gyrus, anterior central gyrus, superior frontal gyrus and parietal lobe. While ReHo decreased in marginal lobe, parahippocampal gyrus, putamen, thalamus,lenticular nucleus, inferior frontal gyrus, middle frontal gyrus, anterior cuneiform lobe and cingulate gyrus. Conclusions ReHo analysis of resting state MRI may discover abnormal brain regions of depression, which may help to explore the pathogenesis of depression.
Key words:  Depressive disorder  Magnetic resonance imaging, resting state  Regional homogeneity

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