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舍曲林联合塞来昔布治疗卒中后抑郁的临床效果
武莉娜许国栋张洪艳宋景贵张朝辉
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摘要:
目的 观察舍曲林联合塞来昔布治疗卒中后抑郁(PSD)的临床疗效及安全性。方法 将 2015 年5 月—2017 年12 月在新乡医学院第三附属医院神经内科住院治疗的PSD 患者60 例随机分为两 组,研究组(30 例)和对照组(30 例),均给予常规内科药物治疗。研究组在常规内科药物治疗基础上加服 盐酸舍曲林片和塞来昔布胶囊,对照组用安慰剂替代塞来昔布胶囊,余均同研究组,两组疗程均为6 周。 使用汉密尔顿抑郁量表(HAMD)、不良反应症状量表于治疗前及治疗1、2、4、6 周后评估疗效和安全性。 结果 经6周治疗,研究组有效率为83.33%(25/30),对照组有效率为76.67%(23/30),两组差异有统计学意 义(χ2=6.75,P<0.05)。在治疗第1、2、4、6周时研究组HAMD评分均低于对照组,且差异有统计学意义(P< 0.05)。 两组病例不良反应发生率[23.33%(7/30)比20.00%(6/30)]比较差异无统计学意义(P > 0.05),且不良 反应均较轻。结论 舍曲林联合塞来昔布治疗PSD的临床疗效优于单用舍曲林,且起效快,安全性相当。
关键词:  舍曲林  塞来昔布  卒中后抑郁  疗效  安全性
DOI:10.3969/j.issn.1009-6574.2018.11.009
基金项目:国家自然科学基金项目(81471349)
Clinical observation of sertraline combined with celecoxib in the treatment of post-strokedepression
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Abstract:
Objective To observe the efficacy and safety of sertraline and celecoxib in the treatment of post-stroke depression( PSD). Methods From May 2015 to Decemer 2017, a total of 60 patients with PSD in the Neurology Department of the Third Affiliated Hospital of Xinxiang Medical University were randomly divided into study group( n=30) and control group( n=30). Both groups were given conventional medication. The study group was additionally given sertraline and celecoxib, while the control group was given additionally sertraline and placebo for 6 weeks. The efficacy and safety of the two groups were evaluated with the Hamilton Depression table(HAMD) and adverse symptoms scale before treatment and at the 1st, 2nd, 4th, and 6th week after treatment. Results After 6 weeks of treatment, the effective rates of the study group and the control group were 83.3%( 25/30) and 76.67%( 23/30) respectively. There was significant statistical difference between the two groups( χ2=6.75, P<0.05). The HAMD score of the study group at the 1st, 2nd, 4th and 6th week after treatment were all lower than those of the control group, and the differences were statistically significant( P<0.05). There was no statistical significance in the difference of incidence of adverse effect[ 23.33%( 7/30) vs 20.00%( 6/30)]. In addition, the adverse effects were mild. Conclusions The efficacy of sertraline combined with celecoxib in the treatment of PSD was better than that of sertraline alone. It takes effect more quickly than sertraline alone. But the safety of sertraline combined with celecoxib in the treatment of PSD was comparable to that of sertraline alone.
Key words:  Sertraline  Celecoxib  Post-stroke depression  Efficacy  Safety

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