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组织型纤溶酶原激活剂与阿尔茨海默病的相关研究 进展
王兴鲁江沛王海洋冯清燕闫中瑞
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摘要:
组织型纤溶酶原激活剂(tPA)在静脉溶栓中起着重要的作用,它也参与调节中枢神经系统 的许多其他非纤溶功能,有研究表明,tPA 在阿尔茨海默病(AD)病理过程中起着重要的作用,近年来, 对tPA 与AD 的相关性研究成为热点,但作用机制尚不完全明确,现对tPA 与AD 的相关研究进行综述, 提高相关认识。
关键词:  组织型纤溶酶原激活剂  阿尔茨海默病  综述
DOI:10.3969/j.issn.1009-6574.2018.11.017
基金项目:
Research progress of tissue-type plasminogen activator and Alzheimer disease
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Abstract:
Tissue-type plasminogen activator( tPA) plays an important role in intravenous thrombolysis, and it also regulates many other non-fibrinolytic functions in the central nervous system( CNS). Studies have shown that tPA have great effects on the pathological process of Alzheimer disease( AD). In recent years, the correlation between tPA and AD has become a hot spot. However, at present, the mechanism about tPA associated with AD is not fully clear. This article reviews related researches on connection between tPA and AD, so as to improve the awareness of it.
Key words:  Tissue-type plasminogen activator  Alzheimer disease  Review

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