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单胺氧化酶A rs1137070基因多态性与儿童期受虐在维吾尔族双相障碍患者冲动攻击行为中的交互作用
赵宗峰邹韶红佟钙玉张义
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摘要:
目的 探讨单胺氧化酶A(MAOA) rs1137070 基因多态性与儿童期受虐的交互作用对新 疆维吾尔族双相障碍患者冲动攻击行为的影响。方法 通过问卷调查获取环境暴露资料,采用聚合 酶链式反应(PCR)产物直接测序的方法检测184 例双相障碍施暴者和326 例双相障碍无施暴者MAOA 基因rs1137070 位点的多态性。筛选出新疆维吾尔族双相障碍患者冲动攻击行为发生的危险因素。根 据交互作用指标判断rs1137070 与儿童期受虐的交互作用。结果 新疆维吾尔族男性双相障碍患者 施暴组与无施暴组rs1137070 等位基因频率差异有统计学意义(χ2=11.499,P=0.001),新疆维吾尔族女 性双相障碍患者施暴组与无施暴组rs1137070 基因型(χ2=14.677,P=0.001)及等位基因(χ2=17.753, P< 0.001)频率差异有统计学意义。儿童期受虐是新疆维吾尔族双相障碍患者冲动攻击行为的危险因 素(χ2=9.770,P=0.002)。儿童期受虐与rs1137070基因多态性存在正交互作用,两者的超额相对危险度、 交互作用归因比、交互作用指数分别为1.18、0.146 和1.20。结论 新疆维吾尔族双相障碍患者冲动攻 击行为的发生是儿童期受虐因素及遗传危险因素共同作用的结果。
关键词:  双相情感障碍  冲动攻击行为  单胺氧化酶A  儿童期受虐  交互作用
DOI:10.3969/j.issn.1009-6574.2018.06.001
基金项目:国家自然科学基金项目(31360239)
Interaction between monoamine oxidase A rs1137070 gene polymorphism and childhood abuse inimpulsive aggressive behavior in Uygur bipolar disorder patients
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Abstract:
Objective To investigate the effects of interaction between monoamine oxidase A rs1137070 gene polymorphism and childhood abuse on impulsive aggressive behavior in Uygur bipolar disorder patients. Methods The data of environmental exposures were collected with questionnaires. The polymerase chain reaction( PCR) product direct sequencing was used to detect the polymorphism of the MAOA gene rs1137070 loci in 184 bipolar disorder with violent patients and 326 bipolar disorder without violent patients. The risk factors of impulsive aggression in Uygur bipolar disorder patients in Xinjiang were screened. The interaction between rs1137070 and childhood abuse was identified by interaction indicators. Results The frequency of rs1137070 allele in Xinjiang Uighur male of two groups group was statistically significant (χ2=11.499, P=0.001). The frequency difference of rs1137070 genotype( χ2=14.677, P=0.001) and allele (χ2=17.753, P < 0.001) in the Uygur women of two groups was statistically significant. Childhood abuse was a risk factor for impulsive aggression in Uygur bipolar disorder in Xinjiang( χ2=9.770, P=0.002). There was a positive interaction between childhood abuse and rs1137070 gene polymorphism. RERI, AP and S were 1.18, 0.146 and 1.20 respectively. Conclusions The occurrence of impulsive aggressive behavior in Xinjiang Uygur bipolar disorder patients is the result of the combination of childhood abuse and genetic risk factors.
Key words:  Bipolar disorder  Impulsively behavior  Monoamine oxidase A( MAOA)  Childhood maltreatment  Interaction effects

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