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6例血液内毒素阳性精神分裂症患者的脑脊液内毒素分析
律东林志雄麦奇罗旭东戴准杨志江冼君定廖德权殷静雯 颜海锋王丽静林举达
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摘要:
目的 探讨血液内毒素(LPS)、脑脊液LPS与精神分裂症的相关性。方法 回顾性分析 6 例血液LPS 检测阳性的精神分裂症患者的血液、脑脊液检验结果。结果 6 例患者血液LPS 水平为 0.063~0.669 EU/ml,脑脊液LPS水平为0~1.018 EU/ml,其中4例阳性。3例血液白细胞计数>10×109/L, 1例中性粒细胞>70%;血清抗链球菌溶血素O(ASO)为25~606 IU/ml,其中1例ASO>116 IU/ml。结论 血 液LPS 阳性的精神分裂症患者,部分脑脊液LPS 阳性,考虑感染与精神分裂症的发病相关,脑外细菌感 染可能是精神分裂症的始发病因。
关键词:  精神分裂症  内毒素类  隐性感染
DOI:10.3969/j.issn.1009-6574.2018.06.011
基金项目:
Endotoxin analysis of cerebrospinal fluid in six patients with blood endotoxin positive schizophrenia
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Abstract:
Objective To explore the correlation between lipopolysaccharide( LPS) in blood endotoxin and cerebrospinal fluid( CSF) and schizophrenia. Methods The blood and cerebrospinal fluid test results of 6 schizophrenic patients with positive blood LPS test were retrospectively analyzed. Results The LPS in blood was 0.063-0.669 EU/ml, and the LPS in CSF was 0-1.018 EU/ml. There were 4 positive cases. There were 3 cases of White Blood Count( WBC) higher than 10×109/L,and 1 patient of neutrophile granulocyte( NE%) more than 70%. The antistreptolysin O( ASO) were from 25 to 606 IU/ml, moreover 1 patient' ASO were higher than 116 IU/ml. Conclusions The LPS in CSF are positive in some schizophrenic patients who were positive hematal LPS. Therefore we assume that infection may be related to schizophrenia, and the brain external infection may be the pathogenesis of schizophrenia.
Key words:  Schizophrenia  Endotoxins  Covert infection

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