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同步放化疗对脑胶质瘤患者外周血T淋巴 细胞亚群的影响
康庄李岩张红梅陈建新康勋李珊李文斌
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摘要:
目的 观察同步放化疗对胶质瘤患者外周血T淋巴细胞亚群的影响,为脑胶质瘤的治疗 提供免疫学指标。方法 以2015 年1 月—2017 年12 月北京世纪坛医院脑胶质瘤科收治的脑胶质瘤患 者150 例为脑胶质瘤组,以同期在本院健康体检中心行体格检查的150 例健康人群为对照组。采用流式 细胞仪技术测定健康对照组和脑胶质瘤患者同步放化疗前后外周血T淋巴细胞亚群的含量。结果 结 果显示治疗前胶质瘤患者外周血CD3+与健康对照组差异无统计学意义(P > 0.05),CD4+、CD4+/CD8+ 显 著低于健康对照组,CD8+显著高于健康对照组,差异有统计学意义(P< 0.05);脑胶质瘤患者同步放化 疗前CD3+、CD4+、CD4+/CD8+明显高于放化疗后,差异有统计学意义(P<0.05);同步放化疗后CD8+较放化 疗前明显上升,差异有统计学意义(P<0.05)。结论 脑胶质瘤患者免疫功能下降,同步放化疗后免疫功 能下降更加明显。外周血T淋巴细胞亚群检测可作为临床评估脑胶质瘤同步放化疗的免疫学参考指标。
关键词:  神经胶质瘤  T淋巴细胞  同步放化疗
DOI:10.3969/j.issn.1009-6574.2018.09.003
基金项目:
Effects of concurrent radiochemotherapy on peripheral blood T lymphocytes subsets in patients withglioma
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Abstract:
Objective To observe the effects of concurrent radiochemotherapy on peripheral blood T lymphocyte subsets in patients with glioma, so as to provide immunological indicators for the treatment of glioma. Methods A total of 150 patients with glioma admitted to the glioma department of Beijing Shijitan Hospital from January 2015 to December 2017 were recruited into the glioma group, and the other 150 healthy people who undertook health examination in the health examination center were assigned into the control group. The content of T lymphocyte subsets in peripheral blood of healthy control group and glioma patients before and after concurrent chemoradiotherapy were determined by fluorescence- activated cell sorter( FACS). Results The results showed that there was no statistical significance in the difference of CD3+ in peripheral blood of patients between the two groups before treatment( P>0.05). with glioma was not statistically significant (P > 0.05). The mean CD4+ and CD4+/CD8+ were significantly lower than those in healthy controls. The mean CD8+ was significantly higher than the healthy control group. The difference was statistically significant( P < 0.05). The mean CD3+, mean CD4+ and CD4+/CD8+ of glioma patients before concurrent chemoradiotherapy were significantly higher than those after concurrent chemoradiotherapy, and the difference was statistically significant( P<0.05). The mean value of CD8+ was significantly increased after treatment, and the difference was statistically significant( P<0.05). Conclusions The immune function of patients with glioma is decreased. The defection in immune function after concurrent chemoradiotherapy is more obvious. Peripheral blood T lymphocyte subsets can be used as an immunological reference index for clinical evaluation of glioma concurrent chemoradiotherapy.
Key words:  Glioma  T lymphocytes  Concurrent chemoradiotherapy

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