引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 27次   下载 58  
老年慢性精神分裂症患者的叶酸辅助治疗效果
琚明亮龙彬
0
()
摘要:
目的 探讨叶酸对老年慢性精神分裂症患者的辅助治疗作用。方法 对100 例老年慢性 精神分裂症患者按随机数字表分为对照组和研究组,给予研究组患者叶酸10 mg/d 口服干预,对治疗前 后两组血红蛋白、红细胞计数、血同型半胱氨酸、叶酸水平以及简易智力状态检查量表(MMSE)、威斯康 星卡片分类测试(WCST)评估结果进行对比分析。结果 经叶酸干预后,与对照组比较,研究组叶酸水 平升高,同型半胱氨酸水平降低,血红蛋白、红细胞计数均升高(P< 0.05),与组内治疗前比较差异有统 计学意义(P<0.05)。研究组治疗后阴性量表评分降低,完成分类数提高,与对照组和治疗前比较,差异 均有统计学意义,而MMSE评分差异均无统计学意义。结论 老年慢性精神分裂症患者给予叶酸辅助治 疗,可以改善患者的贫血等躯体症状,还可以对患者的阴性症状和认知症状起到一定程度的改善作用。
关键词:  精神分裂症  叶酸  阴性症状  认知功能
DOI:10.3969/j.issn.1009-6574.2018.09.009
基金项目:上海市精神卫生中心资助项目(2017-YJ-18)
Analysis of folic acid adjuvant therapy in elderly patients with chronic schizophrenia
()
Abstract:
Objective To investigate the effects of folic acid on elderly patients with chronic schizophrenia. Methods A total of 100 cases of elderly patients with chronic schizophrenia were divided into control group and study group by random number table method. Patients in the study group were given oral intervention of 10 mg/d folic acid. The results of hemoglobin, red blood cell count, blood homocysteine (Hcy), folic acid level and Mini-mental State Examination( MMSE) and Wisconsin Card Sorting Test( WCST) were compared and analyzed before and after treatment. Results After folic acid intervention, compared with the control group, the level of folic acid in the study group increased, the Hcy level decreased, while the hemoglobin and red blood cell count increased. And the differences were statistically significant compared with those before treatment( P<0.05). After treatment, the score of negative scale decreased and the number of completed classifications increased in the study group. The difference between the control group and the treatment group was statistically significant, but the difference of MMSE score was not statistically significant. Conclusions Folic acid adjuvant therapy for elderly patients with chronic schizophrenia can improve the physical symptoms such as anemia, and also can improve the negative symptoms and cognitive symptoms of patients to a certain extent.
Key words:  Schizophrenia  Folate acid  Negative symptoms  Cognitive function

用微信扫一扫

用微信扫一扫