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创伤后应激障碍与血同型半胱氨酸、叶酸及维生素 B12的相关性
李国正钟文波张志斌杨敏宋永斌
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摘要:
目的 探讨创伤后应激障碍(PTSD)患者应激症状与血同型半胱氨酸、叶酸、维生素B12 代 谢的相关性。方法 2016 年11 月—2017 年11 月对驻疆某部官兵经历创伤性事件后,按照创伤后应激 障碍筛查量表(PCL-C)评分阳性和美国精神疾病诊断统计手册第五版(DSM-5)的诊断标准,根据是否为 PTSD分为PTSD组(n=27)和在相同暴露条件下的未患PTSD的对照组(n=39)。对两组空腹血浆同型半胱 氨酸、叶酸、维生素B12 及部分其他血液学指标进行分析。结果 PTSD组血同型半胱氨酸水平高于对照 组,叶酸、维生素B12 水平、T3、T4低于对照组,差异均有统计学有意义,而TSH、LDL、HDL-C 组间比较, 差异均无统计学意义。结论 PTSD患者其血同型半胱氨酸较高,叶酸及维生素B12 水平较低。
关键词:  创伤后应激障碍  同型半胱氨酸  叶酸  维生素B12
DOI:10.3969/j.issn.1009-6574.2018.09.010
基金项目:军队后勤科研计划(CLJ16J006)
Correlation between post-traumatic stress disorder and blood homocysteine, folic acid and vitaminB12
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Abstract:
Objective To explore the relationship between posttraumatic stress disorder( PTSD) stress symptoms and blood homocysteine, folic acid, and vitamin B12 metabolism. Methods From November 2016 to November 2017, officers and soldiers stationed in Xinjiang were divided into PTSD group( n=27) and non-PTSD group( n=39) according to the positive result of PTSD Checklist- Civilian Version( PCL-C) and Diagnostic and the diagnostic criteria of Statistical Manual of Mental Disorder( DSM-5). The fasting plasma homocysteine, folic acid, vitamin B12 and some other hematological indexes in the two groups were analyzed. Results The levels of serum homocysteine, folic acid, vitamin B12, T3 and T4 were significantly different between the two groups. However, there was no statistical difference in TSH, LDL, HDL-C. Conclusions The plasma homocysteine is higher in PTSD patients, folic acid and vitamin B12 are lower.
Key words:  Post-traumatic stress disorder  Homocysteine  Folic acid  Vitamin B12

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