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奥氮平对精神分裂症患者血清血管内皮生长因子 水平的影响及其与临床疗效的关系
肖文焕陈宽玉叶飞张晓斌
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摘要:
目的 探讨奥氮平对首发精神分裂症患者血清血管内皮生长因子(VEGF)水平的影响 及其与临床疗效的关系。方法 纳入40 例首发精神分裂症患者(患者组),经4 周单一奥氮平治疗,采 用阳性与阴性症状量表(PANSS)评估疗效。用酶联免疫吸附法测定患者治疗前后和40 名健康者(对 照组)血清VEGF 的水平。结果 患者组服药前血清VEGF 水平[(331.8±80.1)pg/ml]显著低于对照组 [(506.1±211.5)pg/ml],服药后血清VEGF 水平[(475.7±128.5)pg/ml]较治疗前明显上升,差异有统计 学意义(t=6.489,P< 0.05),而与对照组比较差异无统计学意义(P> 0.05);患者组服药后PANSS 评分低 于服药前(P< 0.05),并且PANSS 总分减分率与血清VEGF变化呈正相关(r=0.439,P=0.005)。结论 血 清VEGF水平适合作为精神分裂症的生物标志物,有效的抗精神病治疗能提高血清VEGF水平,血清 VEGF 变化可能是评价抗精神病药物疗效的相关指标。
关键词:  精神分裂症  血管内皮生长因子类  奥氮平
DOI:10.3969/j.issn.1009-6574.2018.09.011
基金项目:江苏省扬州五台山医院科研课题(YKT2016007)
Effects of olanzapine on serum levels of vascular endothelial growth factor in schizophrenic patientsand its relationship with clinical efficacy
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Abstract:
Objective To investigate the effects of olanzapine on serum vascular endothelial growth factor( sVEGF) levels in first-episode schizophrenic patients and its relationship with clinical efficacy. Methods A total of 40 first-episode schizophrenic patients( patients group) were enrolled in the study. They were treated with olanzapine only for 4 weeks. The psychiatric symptoms were estimated using the Positive and Negative Syndrome Scale( PANSS). sVEGF levels were determined in patients and 40 normal controls( normal group) using enzyme linked immunosorbent assay( ELISA). Results Before treatment, the sVEGF levels in the patient group was( 331.8±80.1) pg/ml, which were significantly lower than that in the normal group (506.1±211.5) pg/ml. The sVEGF level after taking drug was( 475.7±128.5) pg/ml, which was higher than before, and the difference was statistically significant( t=6.489,P < 0.05). However there was no significant difference when compared with the control group( P> 0.05). The PANSS score of the patients was lower than that of the patients before treatment, and PANSS reductive ratio was positively correlated with sVEGF changes (r=0.439, P=0.005). Conclusions It is suggested that sVEGF may be an suitable biomarker for schizophrenia. Effective antipsychotic drugs can increase the sVEGF level and the change of sVEGF may be a correlation index of the antipsychotic drugs efficiency.
Key words:  Schizophrenia  Vascular endothelial growth factors  Olanzapine

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