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不同严重程度的首发抑郁症患者的血清游离甲状腺素 水平
宋子龙马童星张聪沛
0
()
摘要:
目的 探讨不同严重程度的抑郁症患者血清中游离三碘甲状腺原氨酸(FT3)、游离甲状腺 素(FT4)、促甲状腺素(TSH)水平。方法 选择2017 年9 月—2018 年4 月在哈尔滨市第一专科医院的住 院地首发抑郁症患者(105 例),以及2017 年10 月本院参与体检的职工(57 人)为研究对象,根据HAMD- 24 评分值将抑郁症患者分为3 个亚组:轻度(33 例)、中度(44 例)、重度(28 例)抑郁组。检测4 组人群的 FT3、FT4 及TSH 水平并比较。结果 4 组人群TSH差异无统计学意义(F=0.687,P=0.561);重度抑郁组 的FT3 均高于健康对照组、轻度和中度抑郁组(P< 0.01);健康对照组、轻度和中度抑郁组3 组之间FT3 差异均无统计学意义(P> 0.05);轻度、中度、重度抑郁组中FT4 均高于健康对照组(P< 0.05),但3 个抑 郁组间比较差异均无统计学意义(P > 0.05)。结论 血清中FT4 相对水平的高低可能预示着是否存在 抑郁的症状,而抑郁症血清中FT3相对水平的高低可能预示着病情的严重程度。
关键词:  抑郁  游离三碘甲状腺原氨酸  游离甲状腺素  促甲状腺素  严重程度
DOI:10.3969/j.issn.1009-6574.2019.01.013
基金项目:
Study on the level of free thyroxin in first-episode depressions with varied severity
()
Abstract:
Objective To investigate the levels of free triiodothyronine( FT3), free thyroxine( FT4) and thyroid stimulating hormone( TSH) in patients with depression of different severity. Methods The 105 first episode depression inpatients in the First Specialized Hospital of Harbin from September 2017 to April 2018 and the employees who participated in the physical examination in the hospital in October 2017 were selected as the research subjects. The depression patients were divided into 3 sub-groups according to the Hamilton Depression Scale( HAMD-24) score, namely mild depression group( n=33), moderate depression group( n=44) and severe depression group( n=28). The levels of FT3, FT4 and TSH were tested by Autolumo A2000. Results There was no significant difference in TSH among the four groups( F=0.687,P=0.561). The FT3 level of the severe depression group was higher than that of the healthy group, the mild depression group and the moderate depression group( P < 0.01). There was no statistical significance in the difference of FT3 among the health group, mild depression group and moderate depression group( P>0.05). The level of FT4 of the 3 depression groups were all higher than that of the health group( P<0.05), however there was no statistical significance in the difference among the 3 depression groups( P>0.05). Conclusions The relative level of FT4 in serum may indicate the existence of depressive symptoms, while the relative level of FT3 in serum of depressive patients may indicate the severity of the disease.
Key words:  Depression  Free triiodothyronine  Free thyroxine  Thyrotropin  Severity

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