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双相情感障碍患者冲动攻击行为与5-HTR1B 基因的关联性研究
贺长兴邹韶红赵宗峰贾丽娜
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摘要:
目的 探讨维吾尔族及汉族双相情感障碍(BPD)患者的冲动攻击行为与5-HTR1B rs6296 基因多态性的关联性。方法 采用病例-对照的研究方法共收集868 例BPD 抑郁发作期患者,根据民 族和有无冲动攻击行为分为4组:维吾尔族BPD 患者有冲动攻击行为组184例(男性92例、女性92 例)、无 冲动攻击行为组326 例(男性174 例、女性152 例),汉族BPD 患者有冲动攻击行为组112 例(男性50 例、 女性62 例)、无冲动攻击行为组246 例(男性134 例、女性112 例)。采用修改版外显行为攻击量表(MOAS) 对入组患者评估。通过PCR直接测序法对rs6296基因多态性进行鉴定。结果 汉族BPD患者有冲动攻 击行为组与无冲动攻击行为组5-HTR1B rs6296 位点的基因型及等位基因频率分布差异均无统计学意义 (P> 0.05);维吾尔族有冲动攻击行为组与无冲动攻击行为组5-HTR1B rs6296 位点基因型及等位基因频 率分布差异均有统计学意义(P < 0.05)。结论 汉族BPD患者冲动攻击行为与5-HTR1B rs6296 基因多 态性无相关性。维吾尔族BPD 患者冲动攻击行为与5-HTR1B rs6296 基因多态性有相关性。等位基因G 可能增加维吾尔族BPD 患者的冲动攻击行为的风险。
关键词:  双相情感障碍  多态性,单核苷酸  冲动攻击  5- 羟色胺受体
DOI:10.3969/j.issn.1009-6574.2019.03.004
基金项目:国家自然科学基金项目(31360239)
Correlation between impulsive aggression behavior and 5-hydroxytryptamine 1B receptor in patientswith bipolar disorder
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Abstract:
Objectives To investigate the correlation between impulsive aggression behavior and 5-hydroxytryptamine 1B receptor( 5-HTR1B) rs6296 gene polymorphisms in both Uygur and Han patients with bipolar disorder. Methods A total of 868 patients with bipolar disorder were collected in a case-control study. There were 184 Uygur bipolar patients( 92 males and 92 females) in the impulsive aggression group, and 326 Uygur bipolar patients( 174 males and 152 females) in the no impulsive aggression group. There were 112 Han bipolar patients( 50 males and 62 females) in the impulsive aggression group, and 246 Han bipolar patients (134 males and 112 females) in the no impulsive aggression group. Patients were assessed using the modified overt aggression scale( MOAS). The polymorphisms of rs6296 were identified by PCR direct sequencing, and the differences of 5-HTR1B rs6296 polymorphisms were analyzed. Results No significant difference in the genotype and allele frequency of rs6296 was found between the impulsive aggression group and no impulsive aggression group in Han bipolar patients( P>0.05). However, significant differences in the genotype and allele frequency of rs6296 were found between the impulsive aggression group and no impulsive aggression group in Uygur bipolar patients( P <0.05). Conclusions There was no correlation between impulsive aggression behavior and 5-HTR1B rs6296 polymorphisms in Han bipolar patients. However, the impulsive aggression behavior in Uygur bipolar patients is closely related to the rs6296 genotype and allele polymorphism of 5-HTR. At the same time, allele G may increase the risk of impulsive aggression behavior in patients in Uygur bipolar group.
Key words:  Bipolar disorder  Polymorphism  Single nucleotide  Impulsive aggression  5-hydroxytrytamine receptor

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