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骨形态发生蛋白-7与急性脑梗死的严重程度及预后 的相关性
康凯佡剑非
0
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摘要:
目的 探究骨形态发生蛋白7(BMP-7)与急性脑梗死(ACI)患者的病情严重程度及预后的 关系。方法 2017 年9 月至2018 年3 月收集105 例ACI患者(ACI组)及同期105 例来院就诊的健康体检 者(对照组),检测血清BMP-7 水平,同时统计所有入组者的相关临床资料。对ACI 组患者随访3 个月并 进行改良Rankin 量表(mRS)评分。对比ACI 组和健康对照组BMP-7 水平的差异,以及观察ACI 组BMP-7 水平与病情严重程度及预后的关系。结果 ACI 组患者的BMP-7 水平低于对照组,Logistic 回归结果显 示吸烟、高血压、胱抑素C、糖化血红蛋白、BMP-7 水平等均与ACI 的发病密切相关(P < 0.05)。ACI患 者中轻症组的BMP-7水平61.54(58.46,66.32)pg/ml高于重症组54.69(51.18,58.27)pg/ml。且BMP-7水平与 ACI组患者的NIHSS评分呈负相关(r=-0.702,P<0.05)。ACI患者中预后不良组BMP-7的水平低于预后良 好组(P<0.05)。BMP-7水平与ACI患者的mRS评分呈负相关(r=-0.493,P<0.05)。结论 BMP-7 是ACI发 病的影响因素,且BMP-7水平可用于评价ACI患者病情的严重程度及预测急性脑梗死患者的预后。
关键词:  脑梗死  骨形态发生蛋白质类  神经功能缺损  预后
DOI:10.3969/j.issn.1009-6574.2019.03.015
基金项目:2012 年辽宁省第一批科学技术计划项目(2012225021)
Relationship between serum BMP-7 and acute cerebral infarction
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Abstract:
Objective To investigate the relationship between bone morphogenetic protein-7( BMP- 7) level and the severity and prognosis of patients with acute cerebral infarction( ACI). Methods A total of 105 patients with ACI( ACI group) and 105 healthy people( control group) were recruited from September 2017 to March 2018. The serum BMP-7 level was measured and the clinical data of all patients were recorded. The patients in ACI group were followed up for 3 months and their Modified Rankin Scores( mRS) were recorded. The difference of BMP-7 level in ACI group and healthy control group, and the relationship between BMP- 7 level and severity and prognosis in ACI group were observed. Results The level of BMP-7 in ACI group was lower than that in the control group. The result of Logistic regression showed that smoking, hypertension, diabetes, coronary heart disease, cystatin C, glycosylated hemoglobin, and BMP-7 levels are closely related to the incidence of ACI( P < 0.05). The level of BMP-7 in less severe ACI group was 61.54(58.46,66.32), which was higher than that in severe group 54.69(51.18,58.27). The level of BMP-7 was negatively correlated with the score of the National Institutes of Health Stroke Scale( NIHSS)( r=-0.702,P < 0.05). The level of BMP-7 in patients with poor prognosis was lower than that in patients with good prognosis( P < 0.05). There was a negative correlation between the level of BMP-7 and mRS score of ACI patients( r=-0.493,P< 0.05). Conclusions BMP-7 is an influential factor in the pathogenesis of ACI, and the level of BMP-7 can be used to evaluate the severity of ACI and predict the prognosis of patients with ACI.
Key words:  Brain infarction  Bone morphogenetic proteins  Nerve function defect  Prognosis

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