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神经调节蛋白1 在髓鞘生成中的相关调控因子研究 进展
李旭光刘丹井珊珊钟镝
0
()
摘要:
髓鞘是包裹在神经轴突外面的一层髓磷脂膜,对于神经电信号的快速传导有着重要作用。 自轴突和细胞外基质的信号参与髓鞘的生成并发挥关键性作用。研究表明,神经轴突及施万细胞可分 泌神经调节蛋白1( NRG1),且NRG1对于施万细胞的分化、增殖、迁移及髓鞘形成、修复存在重要作用。 但NRG1 与其他参与髓鞘形成的信号蛋白(层黏连蛋白-211、Maf、Gab1、E-钙黏蛋白)的相互调控尚不 完全清楚。现主要对此作一综述,以进一步诠释髓鞘生成中的分子机制。
关键词:  神经调节蛋白1  髓鞘生成  调控  信号蛋白  综述
DOI:10.3969/j.issn.1009-6574.2019.03.021
基金项目:
Advances in research on related regulatory factors of neuregulin 1 in myelination
()
Abstract:
The myelin sheath is a layer of myelin membrane that is wrapped around the axons. It plays an important role in the rapid conduction of nerve electrical signals. The production of myelin is a complex dynamic process in which signals from axons and extracellular matrices participate and play a key role. Neuregulin 1( NRG1) is a group of trophic factors. Studies have shown that axons and Schwann cells can secrete NRG1, and NRG1 plays an important role in the differentiation, proliferation, migration and myelination and repair of Schwann cells. However, the regulation of NRG1 with other signaling proteins involved in myelination (laminin-211, Maf, Gab1, E-cadherin) is not fully understood. This article is mainly to review this to further explain the molecular mechanism of myelination.
Key words:  Neuregulin 1  Myelin production  Regulatory  Signal protein  Review

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