引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 1847次   下载 1030  
路易体痴呆与帕金森病痴呆的神经心理学特征比较
左秀美周爱红魏翠柏王芬秦伟贾建平
0
()
摘要:
目的 比较路易体痴呆(DLB)和帕金森病痴呆(PDD)患者神经心理学特征的差异。方法 采用简易精神状态检查量表(Mini-mental State Examination,MMSE)、画钟测验(Clock-drawing Test,CDT)、神经精神问卷(Neuropsychiatric Inventory,NPI)、日常活动能力量表(Activities of Daily Living Scale,ADL)、汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)17项版本、临床痴呆评定量表(Clinical Dementia Rate,CDR)评估 20例DLB患者和56例 PDD患者的认知功能,并比较不同痴呆阶段的两组患者神经心理学差异。结果 60%的 DLB患者存在症状的波动,多于PDD患者( 19.6%)(P=0.001)。中重度痴呆阶段, DLB 组NPI评分高于 PDD组(P< 0.05)。轻度痴呆阶段, PDD患者在 CDR的家庭生活和个人业余爱好域评分高于 DLB患者( P=0.039)。中重度痴呆阶段, DLB组记忆力(P=0.018)和定向力评分(P=0.010)以及 CDR总体得分(P=0.028)高于 PDD组。结论 临床工作中结合病史并对痴呆患者进行全面的神经心理学检查有助于鉴别 DLB和PDD。
关键词:  神经心理学  诊断  路易体痴呆  帕金森病痴呆  严重程度
DOI:10.3969/j.issn.1009-6574.2017.05.004
基金项目:国家自然科学基金(81530036,81100799)北京市医院管理局扬帆计划(ZYLX201301)
Comparison of neuropsychological profile between patients with dementia with lewy bodies and Par-kinson disease dementia
()
Abstract:
Objective To compare the differences of neuropsychological profile between patients with dementia with lewy bodies (DLB)and Parkinson disease dementia (PDD). Methods A total of 20 DLB patients and 56 PDD patients were recruited in this study. Mini-mental State Examination(MMSE),Clock-draw-ing Test (CDT),Neuropsychiatric Inventory (NPI),Activities of Daily Living Scale (ADL),Hamilton Depression Scale(HAMD)and Clinical Dementia Rate (CDR)were used to evaluate the cognitive function. Results A total of 60% of DLB patients had fluctuant symptoms,significantly higher than PDD patients (19.6%,P=0.001). In the moderate and severe stage of dementia,the NPI scores of DLB group were significantly higher than that of PDD group (P< 0.05). In the mild dementia stage,the scores of the family life and personal hobby domain in CDR were higher in PDD patients than that in DLB patients (P=0.039). In the moderate and severe stage,the memory score (P=0.018),orientation score (P=0.010)and overall CDR score (P=0.028)in DLB group were higher than that in PDD group. Conclusions Comprehensive neuropsychological tests combined with clinical historycan help identify DLB and PDD in dementia patients.
Key words:  Neuropsychology  Diagnosis  Dementia with lewy bodies  Parkinson disease demen-tia  Severity

用微信扫一扫

用微信扫一扫