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育阴潜阳汤对抗精神病药所致帕金森综合征患者生活质量的影响
闵茗段俞戎杨程青范慧斌朱丽萍吴海苏
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摘要:
目的 探讨育阴潜阳汤治疗抗精神病药物所致帕金森综合征的疗效及对生活质量的影 响。方法 应用随机、双盲、对照的研究方法,将120 例抗精神病药物所致帕金森综合征患者随机分 为研究组和对照组各60 例,分别予以育阴潜阳汤结合安坦安慰剂和安坦结合育阴潜阳汤安慰剂治疗。 两组治疗时间12 周,分别于治疗前、治疗后4、8、12 周末采用不自主运动量表(AIMS)及健康状况问卷 (SF-36)对患者疗效及生活质量进行评价。结果 研究组对抗精神病药物所致帕金森综合征的疗效等 同于对照组,两组间差异无统计学意义(F=0.186,P > 0.05),但不同的观察时间点间差异有统计学意义 (F=70.180,P< 0.05),不同时间点与组间交互作用不显著(F=0.939,P> 0.05)。研究组在治疗后SF-36 评分在生理功能、生理职能、躯体疼痛、活力、社会功能、情感职能、心理健康、躯体健康总评和精神健 康总评分值明显升高(P<0.05)。治疗前两组间SF-36比较差异无统计学意义,治疗后,研究组在生理职 能、情感职能、心理健康、健康变化自评、躯体健康总评和精神健康总评评分均明显高于对照组(P< 0.05)。 结论 育阴潜阳汤对治疗抗精神病药物所致帕金森综合征疗效与安坦相当,但可改善患者的生活质量。
关键词:  抗精神病药  帕金森综合征  育阴潜阳汤  中医药疗法
DOI:10.3969/j.issn.1009-6574.2018.01.003
基金项目:上海市科学技术委员会科研计划项目(14401932000,16411965100)
Effects of Yuyin Qianyang Decoction on antipsyehotics induced Parkinson syndrome patients' qualityof life
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Abstract:
Objective To explore the curative effects of Yuyin Qianyang Decoction on Parkinson syndrome caused by antipsychotics and its influence on the quality of life. Methods A randomized double blind case control study was designed. A total of 120 antipsychotic induced Parkinson syndrome patients were randomly divided into study group( n=60) and control group( n=60). Patients of the two groups were given Yuyin Qianyang Decoction combine with trihexyphenidyl placebo and trihexyphenidyl combined with Yuyin Qianyang Decoction placebo respectively. All the patients were treated for 12 weeks. Abnormal Involuntary Movement Scale( AIMS) and Mos 36-item Short Form Health Survey( SF-36) were applied to evaluate patients' curative effects and quality of life before treatment and 4, 8 and 12 weeks after treatment. Results There was no statistical difference in curative effects of antipsychotic induced Parkinson syndrome between the study group and control group( F=0.186,P> 0.05). However, there were significant differences among different time points (F=70.180, P<0.05), and the interaction among different time points and groups was not significant( F=0.939, P> 0.05). After treatment, the SF-36 score of the study group increased significantly in physical function, role of physical, bodily pain, vitality, social function, role of emotion, mental health, physical component summary and mental component summary( P < 0.05). Before treatment, there was no statistical difference in SF-36 between the two groups. After treatment, the scores of study group were significantly higher than those of the control group in role physical, role emotional, mental health, reported health transition, physical component summary and mental component summary( P< 0.05). Conclusions The Qianyang Decoction showed almost the same effect as trihexyphenidyl in treating antipsychotic induced Parkinson syndrome, but it can improve the quality of life of the patients.
Key words:  Antipsychotics  Parkinson syndrome  Yuyin Qianyang Decoction  Chinese medicine therapy

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