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生长分化因子-15对神经系统作用的研究进展
于彦段淑荣
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摘要:
生长分化因子-15( growth differentiation factor-15, GDF-15)是一种新的转化生长因子-β (transforming growth factor beta, TGF-β)超家族的成员,关于GDF-15 的研究目前主要集中在其抗炎、抗 细胞增殖以及抑制肿瘤生长方面。在神经系统中,研究者发现GDF-15 是黑质多巴胺能神经元的保护因 子、运动和感觉神经元的新的营养因子、脑血管疾病及脑损伤的预测因子。最新研究表明GDF-15 还具 有调制神经元离子通道的表达、影响突触传递功能的作用。现对GDF-15 的生物学特性以及近年来在神 经系统疾病中的研究进展进行综述。
关键词:  生长分化因子-15  脑梗死  认知障碍  帕金森病  综述
DOI:10.3969/j.issn.1009-6574.2018.01.015
基金项目:
Research progress on the effects of growth differentiation factor-15 on neurological systems
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Abstract:
Growth differentiation factor-15( GDF-15) is a new divergent member of the transforming growth factor-β( TGF-β) superfamily. Research on GDF-15 is currently focused on its anti-inflammatory, anticell proliferation, and inhibition of tumor growth. In the nervous system, researchers found that GDF-15 is a protective factor for nigral dopaminergic neurons, a new trophic factor for motor and sensory neurons, a predictor of cerebrovascular disease and brain damage. Recent studies have shown that GDF-15 also has the function of modulating the expression of neuronal ion channels and affecting the function of synaptic transmission. This review summarizes the biological characteristics of GDF-15 and its recent advances in neurological diseases.
Key words:  Growth differentiation factor-15  Cerebral infarction  Cognition disorders  Parkinson disease  Review

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