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血浆Aβ40、Aβ42水平与无认知功能障碍抑郁症 患者的相关性
高静邬素萍
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()
摘要:
目的 探讨血浆β淀粉样蛋白40、42(Aβ40、Aβ42)水平及两者比值与无认知功能障碍 抑郁症患者的相关性。方法 收治无认知功能障碍未接受过系统治疗的抑郁症患者70 例,纳入患者 组,同期健康体检者70 例作对照组。测量每组血浆Aβ40、Aβ42 水平。采用汉密尔顿抑郁量表24 项 (HAMD-24)评估抑郁严重程度。结果 患者组血浆Aβ40 水平和对照组比较差异无统计学意义(P=0.39); 患者组血浆Aβ42 水平明显低于对照组(P=0.02),Aβ40/Aβ42 水平明显高于对照组(P=0.01),且不受年龄 影响,差异有统计学意义。Aβ42 水平与HAMD24 总分呈负相关关系(r=-0.401,P=0.015),Aβ40/Aβ42 与 HAMD-24 总分呈正相关关系(r=0.461,P=0.005)。结论 认知功能正常的抑郁症患者血浆Aβ42 水平降 低,Aβ40/Aβ42 水平增高,Aβ42、Aβ40/Aβ42 水平变化可能与抑郁症发病有关。
关键词:  抑郁症  β 淀粉样蛋白
DOI:10.3969/j.issn.1009-6574.2019.03.018
基金项目:
Correlation between plasma levels of Aβ40, Aβ42 and depressed patients without cognitive impairment
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Abstract:
Objectives To explore the correlation between plasma amyloid β protein 40, 42( Aβ40, Aβ42) levels and their ratios in depressed patients without cognitive impairment. Methods A total of 70 depressed patients without cognitive impairment who had not gone through systemic treatment were selected as the experimental group. During the same period, a total of 70 healthy cases were selected as the control group. The plasma levels of Aβ40 and Aβ42 in each group were measured. The Hamilton Depression Scale 24( HAMD-24) was used to assess the severity of depression. Results There was no significant difference in plasma Aβ40 level between patients and controls( P=0.39). The level of plasma Aβ42 in the patient group was significantly lower than that in the control group( P=0.02), and the level of Aβ40/Aβ42 was significantly higher than that in the control group( P=0.01). The results were not affected by age and the differences were statistically significant. Aβ42 level was negatively correlated with HAMD24 total score( r=-0.401, P=0.015), while Aβ40/Aβ42 was positively correlated with HAMD-24 total score( r=0.461, P=0.005). Conclusions Depressed patients without cognitive impairment have decreased serum Aβ42 levels and increased Aβ40/Aβ42 levels. The changes of Aβ42 and Aβ40/Aβ42 levels may be associated with the onset of depression.
Key words:  Depressive disorder  Amyloid β-protein

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