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广泛性焦虑障碍患者跨期选择特征的探究
曾瑾王垚庞娇艳李春波
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摘要:
目的 探索广泛性焦虑障碍(GAD)患者跨期选择特征。方法 选取GAD 患者49 例、抑郁 障碍患者67 例和健康对照71 名;运用跨期选择范式,以贴现率K 及曲线下面积(AUC)等指标代表个体 跨期选择的决策倾向。采用组别× 金额大小×延迟时间的混合实验设计。结果 (1)3 组跨期选择总 体上各时点AUC 值差异无统计学意义;(2)对不同金额AUC 值分析发现,GAD 组和抑郁障碍组金额大小 差异无统计学意义,不符合绝对数量原则,健康对照组金额大小差异有统计学意义;(3)对于不同延迟 时点分析发现,50 元金额任务中,GAD 在部分较短时点之间AUC 值差异有统计学意义,抑郁障碍和健 康对照组的贴现趋势与GAD 存在差异;500 元任务中,GAD 各时点间差异有统计学意义,健康对照在部 分时点间差异有统计学意义,而抑郁障碍各时点间差异无统计学意义。结论 GAD 患者存在不同于抑 郁障碍患者和健康对照的贴现趋势,且有着较为敏感的时间感知度。
关键词:  广泛性焦虑障碍  抑郁障碍  跨期选择  贴现率
DOI:10.3969/j.issn.1009-6574.2019.04.012
基金项目:上海交通大学医学院-中国科学院神经科学研究所脑疾病临床研究中心项目(2017NKX003)
Preliminary study on the characteristics of intertemporal choice in patients with generalized anxietydisorder
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Abstract:
Objectives To explore the characteristics of intertemporal choice in patients with generalized anxiety disorder( GAD). Methods A total of 49 patients with GAD, 67 patients with depressive disorder( D) and 71 healthy controls( HC) were selected. Using the intertemporal choice paradigm, the discount rate K and the area under the curve( AUC) were used to represent the decision-making tendency of individual intertemporal choice. A mixed experiment design using Group × Amount Size × Delay Time. Results (1) There was no significant difference in the AUC values across the three groups in the intertemporal choice.( 2) The analysis of AUC values of different amount sizes showed that there was no statistically significant difference in the amount size in the GAD group and the D group. As opposed to the Absolute Quantity Principle, the difference of the amount size in the HC group was statistically significant.( 3) The analysis of different delay time points showed that the difference of AUC value in some short time points in the GAD group was statistically significant in the ¥50 task. The discounting trend of the D group HC group were different from that of the GAD group. In the ¥500 task, the difference of AUC value was statistically significant at different time points in the GAD group. The difference of AUC value was statistically significant at some time points in the HC group. The difference was not statistically significant in the D group. Conclusions Patients with GAD have different discounting trends than those with depression and healthy controls and have more sensitive time perception.
Key words:  Generalized anxiety disorder  Depression disorder  Temporal choice  Discounting rate

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