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抑郁症患者认知功能障碍相关的神经生化指标分析
胡全喜杨雪岭王德民温金峰
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摘要:
目的 研究抑郁症患者神经生化指标与其认知功能障碍的关系。方法 采用MoCA 量 表(中文版)将抑郁症患者分为认知功能受损组和认知功能正常组,通过Logistic 回归分析鉴定其血清 同型半胱氨酸(Hcy)、皮质醇(COR)、硫化脱氢表雄酮(DHEA)、白细胞介素18(IL-18)和脑源性神经营 养因子(BDNF)水平与认知功能障碍的相关性。结果 调整性别、年龄、受教育年限和HAMD-24 评 分后,血清Hcy、COR、DHEA 和IL-18 水平与抑郁症患者的认知功能障碍相关,其比值比(OR)分别是 2.458(95%CI=1.343~4.918)、2.034(95%CI=1.217~4.837)、1.954(95%CI=1.122~4.129)和2.173(95%CI= 1.226~4.909)。结论 抑郁症患者血清Hcy、COR、DHEA 和IL-18 水平与其认知功能障碍相关,可以应 用于抑郁症患者认知功能障碍的预测。
关键词:  抑郁症  认知功能障碍  神经生化指标
DOI:10.3969/j.issn.1009-6574.2019.04.013
基金项目:广东省自然科学基金(2018A0303130044)
Analysis of neurobiochemical markers associated with cognitive dysfunction in patients with depression
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Abstract:
Objectives To study the association between neurobiochemical markers and cognitive dysfunction in patients with depression. Methods Patients with depression were divided into cognitive dysfunction group and normal cognitive function group according to the Chinese version of Montreal Cognitive Assessment( MoCA). Multivariate analysis was performed with binary logistic regression model to identify the association between serum homocysteine( Hcy), corticoid( COR), dehydroepiandrosterone( DHEA), interleukin-18( IL-18), brain-derived neurotrophic factor( BDNF) and cognitive dysfunction in patients with depression. Results After adjusting for gender, age, educational years and the 24-item Hamilton Depression Scale( HAMD-24) scores, serum Hcy, COR, DHEA and IL-18 were associated with cognitive dysfunction in patients with depression, and their odds ratio( OR) were 2.458( 95%CI: 1.343-4.918), 2.034( 95%CI: 1.217- 4.837), 1.954( 95%CI: 1.122-4.129) and 2.173( 95%CI: 1.226-4.909), respectively. Conclusions Serum Hcy, COR, DHEA, and IL-18 were associated with cognitive dysfunction in patients with depression, which might be used in the prediction of cognitive dysfunction in patients with depression.
Key words:  Depression  Cognitive dysfunction  Neurobiochemical markers

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