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阿霉素无水乙醇混合液神经干注射治疗三叉神经痛
李晓宾郭靖欧春影李传玲安晓雷
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摘要:
目的 观察阿霉素无水乙醇混合液神经干注射神经损毁治疗三叉神经痛的近期及远期疗 效。方法 对91 例三叉神经痛患者经皮穿刺三叉神经干,注射阿霉素无水乙醇混合液进行神经毁损治 疗,记录在治疗前、治疗后当日、7 d、1 个月、3 个月、6 个月、1 年、2 年的疼痛视觉模拟评分(VAS)以及疼 痛缓解程度。结果 91 例患者在1 年内的疼痛复发率为5.49%(5/91);治疗后各个时间点的VAS 评分均 较治疗前明显降低(均P< 0.01),治疗后各时间点的VAS 评分均明显低于治疗后当日(均P< 0.01),治疗 后3 个月、6 个月、1 年、2 年的VAS 评分进行两两比较差异均无统计学意义(均P>0.05);治疗后当日、 7 d、1 个月、3 个月、6 个月、1 年、2 年的显效率分别为49.45%、83.52%、 95.60%、94.51%、96.55%、 93.02%、 86.57%;治疗后各时间点的疼痛缓解度平均秩次均明显低于治疗后当日(P< 0.05),治疗后1 个 月、3个月、6个月、1年、2年各时间点的平均秩次均明显低于治疗后7 d(均P<0.01),治疗后1个月、3 个月、 6 个月、1 年、2 年疼痛缓解度的平均秩次进行两两比较差异均无统计学意义(均P> 0.05)。所有患者未 出现严重并发症。结论 阿霉素无水乙醇混合液神经干注射损毁治疗三叉神经痛,操作简便,无严重 并发症发生,具有良好的近期及远期疗效。
关键词:  三叉神经痛  阿霉素  无水乙醇  疼痛治疗
DOI:10.3969/j.issn.1009-6574.2019.04.021
基金项目:
Treatment of trigeminal neuralgia by nerve trunk injection with mixture composed of adriamycinand anhydrous ethanol
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Abstract:
Objectives To observe the short-term and long-term curative effect in the treatment of trigeminal neuralgia by nerve trunk injection for nerve damage treatment with mixture composed of adriamycin and anhydrous ethanol. Methods A total of 91 cases with trigeminal neuralgia patients were treated for nerve damage by transcutaneous puncture and injecting mixture composed of adriamycin and anhydrous ethanol into trigeminal nerve trunk. Pain visual analogue score( VAS) and pain relief level were recorded at the time points of prior treatment, the treatment day and 7 days, 1 month, 3 months, 6 months, 1 year and 2 years after operation. Results The pain recurrence rate of 91 patients within one year was 5.49%( 5/91). VAS score after treatment was significantly lower than that before the treatment at each time point and lower than that on the treatment day (P < 0.01). The differences were all no statistical significance in VAS score by pairwise comparison between 3 months, 6 months, 1 year and 2 years after treatment( P > 0.05). The significant efficiency was 49.45%, 83.52%, 95.60%, 94.51%, 96.55%, 93.02% and 86.57% respectively on the treatment day, and 7 days, 1 month, 3 months, 6 months, 1 year, 2 years after treatment( P<0.05). The mean rank of pain relief level at 7 days,1 month,3 months, 6 months, 1 year and 2 years after treatment were significantly lower than that on the treatment day( P <0.05). The mean rank of each time point at 1 month, 3 months, 6 months, 1 year and 2 years after treatment was significantly lower than that at 7 days after treatment( P < 0.01). There was no statistical significance in the mean rank in pain relief level of 1 month, 3 months, 6 months, 1 year and 2 years after treatment by pairwise comparison( P > 0.05). No serious complications occurred in all patients. Conclusions The treatment of trigeminal neuralgia by nerve trunk injection for nerve damage treatment with mixture composed of adriamycin and anhydrous ethanol is easy to operate and has no serious complications with good short-term and long-term effects.
Key words:  Trigeminal neuralgia  Adriamycin  Anhydrous ethanol  Pain management

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