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雷洛昔芬治疗精神分裂症阴性症状的随机 双盲对照研究
孙秋芳施慎逊褚庆文
0
()
摘要:
目的 探讨雷洛昔芬联合奥氮平治疗对绝经后女性精神分裂症患者阴性症状的影响,并 进一步分析治疗过程中血清雌二醇水平的改变与患者阴性症状的关系。方法 连续入组绝经后女性 精神分裂症患者80 例,按照随机数字表分为研究组和对照组,研究组给予12 周的奥氮平和雷洛昔芬 (60 mg/d)治疗,对照组给予奥氮平和安慰剂治疗,在治疗前和治疗12 周检测患者血清雌二醇水平,同 时采用阳性和阴性症状量表(PANSS)评估患者的精神症状。结果 研究组和对照组治疗前PANSS 总 分、阳性症状分、阴性症状分、一般精神病性症状及血清雌二醇水平差异无统计学意义(P>0.05);治疗12 周 后,研究组PANSS 总分及阴性症状因子分显著低于对照组(P < 0.05),而血清雌二醇水平显著高于对照 组(P < 0.05);治疗前后研究组血清雌二醇水平差值与PANSS 阴性症状分差值呈显著正相关(r=0.434, P=0.005)。结论 加用雷洛昔芬可以显著改善绝经后女性精神分裂症患者的阴性症状以及升高血清雌 二醇含量,并且体内雌二醇含量的变化可能与阴性症状的改善有关。
关键词:  精神分裂症  雌二醇  雷洛昔芬  临床症状  阴性症状
DOI:10.3969/j.issn.1009-6574.2019.06.003
基金项目:上海市宝山区科学技术委员会科技创新专项资金项目(16-E-36)
Randomized double-blind controlled study of raloxifene on negative symptoms of schizophrenia
Sun Qiufang, Shi Shenxun, Chu Qingwen
()
Abstract:
Objective To investigate the effect of raloxifene combined with olanzapine on negative symptoms in postmenopausal women with schizophrenia, and to further analyze the relationship between serum estradiol levels and negative symptoms during treatment. Methods A total of 80 consecutive postmenopausal women with schizophrenia were randomly divided into the study group and the control group according to the random number table. The study group received 12 weeks of olanzapine and raloxifene( 60 mg/d) treatment, and the control group received olanzapine and placebo treatment. Serum estradiol levels were measured before treatment and at 12 weeks of treatment. Psychiatric symptoms were assessed using the Positive and Negative Symptoms Scale( PANSS). Results There was no significant difference in total score of PANSS, positive symptom score P, negative symptom score N, general psychiatric symptom G and serum estradiol level between the study group and the control group before treatment( P>0.05); after 12 weeks of treatment, total score of PANSS and negative symptom score N in the study group were significantly lower than those in the control group (P<0.05), while serum estradiol level was significantly higher than the control group( P<0.05). The difference of serum estradiol level before and after the treatment in the study group was positively related to the difference of the negative symptom scores N( r=0.434,P<0.05). Conclusions Raloxifene can significantly improve the negative symptoms of postmenopausal women with schizophrenia and change the serum estradiol content, and the change of estradiol content in vivo may be related to the improvement of negative symptoms.
Key words:  Schizophrenia  Estradiol  Raloxifene  Clinical symptoms  Negative symptoms

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