引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 37次   下载 95  
小剂量氨磺必利联合草酸艾司西酞普兰对抑郁症 患者疲乏症状的疗效
张俊峰游非戴炜郭青山戴立磊
0
()
摘要:
目的 探讨小剂量磺必利联合草酸艾司西酞普兰对抑郁伴有疲乏症状患者的总体疗效及 耐受性。方法 选择2017 年9 月至2018 年6 月在荆门市口腔医院心理科门诊或住院治疗的抑郁症患者 100 例为研究对象,按照随机数字表法分为研究组和对照组各50 例,对照组口服草酸艾司西酞普兰,研 究组在此基础上合用小剂量的氨磺必利,治疗前后采用汉密尔顿抑郁量表(HAMD-17)和疲乏严重程度 量表(FSS)对患者治疗效果进行评分,评价两组患者总体疗效。结果 (1)两组患者一般资料比较差异 无统计学意义(P> 0.05);(2)两组患者治疗前HAMD 量表评分差异无统计学意义,治疗1 周、2 周及4 周 后,两组患者的HAMD 评分均明显减低,但研究组减分值明显高于对照组,两组比较差异有统计学意义 (P< 0.01);(3)两组患者治疗前FSS 评分差异无统计学意义,治疗2 周末FSS 评分均降低,研究组差异有 统计学意义(P<0.05),而对照组差异无统计学意义(P>0.05);两组患者治疗4周末时FSS评分继续降低, 研究组减分值高于对照组,两组的组内比较及组间比较差异均有统计学意义(均P< 0.05);(4)研究组不 良反应发生率[16%(8/50)]和对照组[14%(7/50)]比较差异无统计学意义。结论 小剂量氨磺必利联 合草酸艾司西酞普兰对于抑郁症患者抑郁情绪及疲乏症状疗效更佳,不良反应相当。
关键词:  抑郁症  氨磺必利  草酸艾司西酞普兰  疲乏症状
DOI:10.3969/j.issn.1009-6574.2019.06.007
基金项目:荆门市科技计划项目(2018YFYB005)
Effectiveness of low-dose amisulpride combined with escitalopram oxalate on fatigue symptoms inpatients with depression
Zhang Junfeng, You Fei, Dai Wei, Guo Qingshan, Dai Lilei
()
Abstract:
Objective To investigate the overall effectiveness and tolerance of low-dose amisulpride combined with escitalopram oxalate in the treatment of depression patients with fatigue symptoms. Methods From September 2017 to June 2018, a total of 100 patients with depression in our hospital were selected as subjects. According to random number table method, the patients were divided into study group and control group, with 50 cases in each group.Tthe control group was given escitalopram oxalate orally, while the study group was given escitalopram oxalate combined with small doses of amisulfapride. Hamilton Depression Scale( HAMD-17) and Fatigue Severity Scale( FSS) were used before and after treatment to evaluate the overall treatment effectiveness in the two groups. Results (1)There was no significant difference in general data between the two groups( P > 0.05).( 2)There was no significant difference in HAMD score between the two groups before treatment. After 1, 2 and 4 weeks of treatment, the HAMD score of the two groups decreased significantly, with the study group's score change significantly more dramatically than the control group( P<0.01). (3)There was no significant difference in the FSS scores between the two groups before treatment. The FSS scores decreased in both groups after 2 weeks of treatment, while the change in the score was only significant for the study group( P<0.05) not for the control group( P>0.05). At the end of 4 weeks of treatment, the FSS scores in both groups continued to decrease, with the study group's score change more dramatically than the control group. There were significant differences between the two groups in intra-group comparison and inter group comparison( P<0.05).( 4)The incidence of adverse reactions was 16%( 8/50) in the study group and 14% (7/50) in the control group. There was no significant difference between the two groups. Conclusions Lowdose amisulfapride combined with escitalopram oxalate is more effective for depression and fatigue symptoms in patients with depression, with similar adverse reactions.
Key words:  Depression  Amisulfapride  Escitalopram oxalate  Fatigue symptoms

用微信扫一扫

用微信扫一扫