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5-羟甲基胞嘧啶与阿尔茨海默病关系的研究进展
蔚然钱正康柳艳松黄月香王妍付晓倩
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()
摘要:
阿尔茨海默病的表观遗传机制日益受到重视,5- 羟甲基胞嘧啶参与的DNA 甲基化是表观 遗传修饰的重要手段,目前研究认为5-羟甲基胞嘧啶参与了阿尔茨海默病的发生、发展,这对进一步 揭示阿尔茨海默病的发病机制有较高的参考价值。现就5-羟甲基胞嘧啶与阿尔茨海默病关系的研究 进行综述。
关键词:  阿尔茨海默病  表观遗传  DNA 甲基化  5- 羟甲基胞嘧啶  综述
DOI:10.3969/j.issn.1009-6574.2019.06.015
基金项目:苏州市科技局产业技术创新专项(SYSD2017141);苏州市医学重点学科建设项目 (Szxk201515);苏州市卫生计生委科技项目(LCZX201719)
Research progress on the relationship between 5-hydroxymethylcytosine and Alzheimer disease
Wei Ran, Qian Zhengkang, Liu Yansong, Huang Yuexiang, Wang Yan, Fu Xiaoqian
()
Abstract:
The epigenetic mechanism of Alzheimer disease( AD) is attracting increasing attention, and 5-hydroxymethylcytosine involved DNA methylation is an important means of epigenetic modification. Recent studies believe that 5-hydroxymethylcytosine is involved in the occurrence and development of AD. This is a very valuable reference for the further revelation the pathogenesis of AD. This article reviews research on the relationship between 5-hydroxymethylcytosine and AD.
Key words:  Alzheimer disease  Epigenetic  DNA methylation  5-hydroxymethylcytosine  Review

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