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单核细胞趋化蛋白-1/C-C趋化蛋白受体2信号 传导参与酒依赖致脑损害的机制进展
孙慧楠胡建
0
()
摘要:
酒依赖对大脑造成严重损害,与大脑萎缩、记忆力和注意力缺陷、交流障碍和身体残疾有 关。单核细胞趋化蛋白-1(MCP-1)是调节单核细胞和小胶质细胞募集和活化的关键趋化因子之一,与 其受体C-C 趋化蛋白受体2(CCR2)参与各种神经炎性疾病。最近的证据表明,酒精增加了中枢神经系 统中MCP-1/CCR2 的活性,阻断MCP-1/CCR2 可抑制大脑和脊髓中的神经炎症进而减轻酒精诱导的神 经毒性。现对MCP-1/CCR2 信号在酒精诱导的神经炎症和脑损伤中的作用进行综述。
关键词:  酒依赖  单核细胞趋化蛋白-1  C-C 趋化蛋白受体2  神经炎症  综述
DOI:10.3969/j.issn.1009-6574.2019.06.022
基金项目:
Research progress in alcohol dependence leading to brain damage through MCP-1/CCR2 conduction
Sun Huinan, Hu Jian
()
Abstract:
Alcohol dependence causes profound damage to brain. Alcohol dependence is associated with brain shrinkage, memory and attention deficits, communication disorders and physical disabilities. Monocyte chemoattractant protein-1( MCP-1) is one of the key chemokines that regulate the recruitment and activation of monocytes and microglia. Both MCP-1 and its receptor C-C chemokine receptor type 2( CCR2) are involved in various neuro inflammatory disorders. Recent evidence indicates that alcohol exposure increased the activity of MCP-1/CCR2 in central nervous systems. MCP-1/CCR2 inhibition can alleviate alcohol neurotoxicity by reducing neuro inflammation in the brain and spinal cord. In this review, we discussed the role of MCP-1/ CCR2 signaling in alcohol-induced neuro inflammation and brain damage.
Key words:  Alcohol dependence  Monocyte chemoattractant protein-1  C-C chemokine receptor type 2  Neuro inflammation  Review

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