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银杏萜类内酯治疗认知障碍机制研究进展
颜艺马莉
0
()
摘要:
认知障碍是一种获得性、进行性的智能障碍表现,其认知功能损伤包括学习、记忆、视空 间等多方面能力异常,导致患者出现进行性记忆力下降、日常生活能力下降、精神行为异常等临床表现。 认知障碍的病因复杂,包括阿尔茨海默病和血管性痴呆等。因此,针对多靶点的治疗是改善认知障碍 药物疗效的关键,也是近年研究的热点和难点。银杏萜类内酯具有多靶点、多途径治疗特点,现以银杏 萜类内酯主要成分,即银杏内酯A、B、C 及白果内酯为切入点,从其抗氧化应激、抗炎性反应、抗凋亡等 方面,对其治疗认知障碍作用机制进行探讨。
关键词:  阿尔茨海默病  痴呆,血管性  银杏内酯类  白果内酯  综述
DOI:10.3969/j.issn.1009-6574.2019.06.023
基金项目:
Effective mechanism of ginkgobiloba against dementia: a review of current literature
Yan Yi, Ma Li
()
Abstract:
Cognitive impairment is characterized as an acquired and progressive manifestation of intellectual impairment. Cognitive impairment includes learning, memory, visual space and other abnormal abilities, leading to progressive memory decline, daily living ability decline, mental and behavioral anti-oxidative stress, anti-inflammatory response, anti-apoptosis, etc., to explore its mechanism of treatment of cognitive impairment abnormalities and other clinical manifestations. The pathological mechanism of cognitive impairment is complex, including Alzheimer disease and vascular dementia. Currently, the treatment of multiple targets is the key to improve the efficacy of pharmacotherapy, and it is also possesses the most significant position in recent years. Ginkgobiloba has multi-target and multi-channel treatment characteristics. In this review, we will use the main components of ginkgo biloba lactone, namely ginkgolides A, B, C and bilobalide as the entry point, from its
Key words:  Alzheimer disease  Dementia, vascular  Bilobalides  Bilobalide  Review

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