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急性脑梗死患者血清HIF-1α、sCD40L、CCL3 水平与梗死部位、神经功能缺损的相关性
刘美陈尚超司志旭
0
()
摘要:
目的 探讨急性脑梗死患者血清低氧诱导因子 1α(HIF-1α)、可溶性白细胞分化抗原 40 配体(sCD40L)、趋化因子 CC 基序配体 3(CCL3)水平与梗死部位、神经功能缺损的相关性。方法 选 择 2015 年 1 月至 2018 年 1 月武汉钢铁(集团)公司第二职工医院接诊的 80 例急性脑梗死患者为研究对 象,设为观察组,并选择同期体检健康者 65 例作为对照组,分析血清 HIF-1α、sCD40L、CCL3 与梗死 部位、神经功能缺损的相关性。结果 观察组患者血清 HIF-1α、sCD40L、CCL3 水平显著高于对照组 (P< 0.05);皮层下梗死组患者血清 HIF-1α、sCD40L、CCL3 水平显著高于皮层梗死组患者(P< 0.05); 重度神经功能缺损患者血清 HIF-1α、sCD40L、CCL3 水平显著高于轻度、中度神经功能缺损患者 (P< 0.05);将梗死部位、神经功能缺损作为因变量,将血清 HIF-1α、sCD40L、CCL3 分别作为自变量,相 关性分析结果显示,血清 HIF-1α、sCD40L、CCL3 和梗死部位、神经功能缺损之间均呈正相关(P< 0.05)。 结论 在急性脑梗死患者中 HIF-1α、sCD40L、CCL3 的表达和病情严重程度之间存在着密切关系,可促 使疾病进展。
关键词:  急性脑梗死  缺氧诱导因子 1α  可溶性白细胞分化抗原 40 配体  趋化因子 CC 基 序配体 3  梗死部位  神经功能缺损
DOI:10.3969/j.issn.1009-6574.2019.10.004
基金项目:
Correlation between serum HIF-1 alpha, sCD40L CCL3 levels and the infarction site and neural dysfunction in patients with acute cerebral infarction
Liu Mei, Chen Shangchao, Si Zhixu
()
Abstract:
Objective To discuss the correlation between serum hypoxia inducible factor 1alpha (HIF-1α), soluble leukocyte differentiation antigen 40 Ligand (sCD40L), chemokine CC motif ligand 3 (CCL3) levels and the infarction site and neural dysfunction in patients with acute cerebral infarction. Methods A total of 80 patients with acute cerebral infarction treated in our hospital from January 2015 to January 2018 were selected as the observation group, and 65 healthy patients in our hospital were selected as the control group. The correlation between serum HIF-1α,sCD40L,CCL3 and infarct site and neurological dysfunction was analyzed. Results Serum levels of HIF-1α, sCD40L and CCL3 in the observation group were significantly higher than those in the control group (P< 0.05). Serum levels of HIF-1α, sCD40L and CCL3 in subcortical infarction group were significantly higher than those in cortical infarction group (P< 0.05). Serum levels of HIF- 1α, sCD40L and CCL3 in patients with severe neurological impairment were significantly higher than those in patients with mild and moderate neurological impairment (P<0.05). When the infarction site and nerve function defect were taken as dependent variables, and serum HIF-1α, sCD40L and CCL3 were taken as independent variables, the correlation analysis results showed that serum HIF-1α, sCD40L and CCL3 were positively correlated with the infarction site and nerve function defect (P < 0.05). Conclusions In patients with acute cerebral infarction, there is a close relationship between the expression of HIF-1 alpha, sCD40L and CCL3 and the severity of the disease, which can promote the progression of the disease.
Key words:  Acute cerebral infarction  Hypoxia inducible factor 1 alpha  Soluble leukocyte differentiation antigen 40 ligand  Chemokine CC motif ligand 3  Infarct site  Neurological deficit

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