引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 2227次   下载 2059  
伏硫西汀对抑郁症治疗效果的Meta分析
何如东周欢
0
()
摘要:
目的 系统评价伏硫西汀对抑郁症的治疗效果。方法 检索 PubMed、Embase、Cochrane Library、中国知网数据库(CNKI)、万方数据库,检索时间均为建库至 2019 年 3 月,纳入伏硫西汀治 疗抑郁症的随机安慰剂对照试验并进行 Meta 分析。结果 13 个随机对照试验共 6 261 例抑郁患者 符合纳入标准。Meta 分析结果显示,对照安慰剂与 5 mg 伏硫西汀组有效率的差异有统计学意义 (RR=1.31,95%CI=1.15~1.49,P< 0.01),与 10 mg 伏 硫 西 汀 组 有 效 率 差 异 有 统 计 学 意 义(RR=1.39, 95%CI=1.26~1.54,P< 0.01),临床治愈率差异有统计学意义(RR=1.37,95%CI=1.19~1.57,P< 0.01), 与 20 mg 伏硫西汀组有效率差异有统计学意义(RR=1.51,95%CI=1.20~1.90,P< 0.01),临床治愈率差异 有统计学意义(RR=1.55,95%CI=1.15~2.10,P< 0.01)。结论 伏硫西汀对照安慰剂对抑郁症有较好的 治疗效果,但结果需要更多较长观察时间的试验验证。
关键词:  抑郁症  Meta 分析  伏硫西汀  疗效
DOI:10.3969/j.issn.1009-6574.2019.10.006
基金项目:
Efficacy of vortioxetine in the treatment of major depressive disorder:A Meta-analysis
He Rudong, Zhou Huan
()
Abstract:
Objective To systematically review the efficacy of vortioxetine in the treatment of depressive disorder. Methods We conducted a Meta-analysis comparing vortioxetine versus placebo in the treatment of depressive disorder. The randomized controlled trials (RCT) were searched up to March 2019 in PubMed, Embase, Cochrane Library, CNKI and Wanfang database. Results A total of 13 RCTs involving 6 261 patients with depressive disorder were identified. The response rate with vortioxetine was significantly higher for 5 mg (RR=1.31,95%CI=1.15-1.49,P < 0.01), 10 mg (RR=1.39,95%CI=1.26-1.54,P < 0.01), 20 mg doses (RR=1.51,95%CI=1.20-1.90,P< 0.01) compared to placebo. Remission rates were significantly higher for the 10 mg group (RR=1.37,95%CI=1.19-1.57,P< 0.01) and the 20 mg group (RR=1.55,95%CI: 1.15-2.10,P < 0.01) compared to placebo. Conclusions Vortioxetine was significantly more effective than placebo for acute treatment of depressive disorder. Nonetheless, more clinical studies of longer observation duration are needed to validate our result.
Key words:  Depressive disorder  Meta-analysis  Vortioxetine  Efficacy

用微信扫一扫

用微信扫一扫