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不同亚型血管内皮生长因子与脑梗死治疗的研究进展
陈亚男何学明
0
()
摘要:
血管内皮生长因子(VEGF)家族在脑梗死的发生发展过程中发挥着重要作用。目前发现 不同亚型的VEGF参与了脑损伤过程中的血管生成、营养代谢、淋巴管生成、神经保护、炎症抑制等过程。 此家族特异的生物学作用为脑梗死的治疗提供了新思路。现综述该家族各亚型在脑梗死发生发展中的 相应作用,以及 VEGF 与脑梗死治疗相关的研究进展及局限。
关键词:  脑梗死  血管内皮生长因子  治疗  综述
DOI::10.3969/j.issn.1009-6574.2019.10.011
基金项目:
Research progress of different subtypes of vascular endothelial growth factor and treatment of cerebral infarction
Chen Yanan, He Xueming
()
Abstract:
Vascular endothelial growth factors (VEGF) family plays a significant role in the development of cerebral infarction. It has been found that different subtypes of VEGF are involved in the process of angiogenesis, nutrient metabolism, lymphangiogenesis, neuroprotection, and inflammation inhibition during brain injury. This family-specific biological role provides a new idea for the treatment of cerebral infarction. This article reviews the corresponding roles of various subtypes of vascular endothelial growth factor in the development of cerebral infarction, and at the same time, the ongoing efforts to address these hotspot targets of VEGF and their limitations in therapeutic terms have been highlighted.
Key words:  Cerebral infarction  Vascular endothelial growth factor  Treatment  Review

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