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CSMD1基因多态性与精神分裂症认知功能关系的 研究进展
袭琢刘薇
0
()
摘要:
精神分裂症是一种严重的精神疾病,大多数患者伴有认知功能的缺陷,给患者、家庭和社 会造成了相当大的负担。精神分裂症的遗传率较高。在过去的十年中,发现许多与精神分裂症有关的 基因变异,从而使人们更好地理解其遗传结构的复杂性。最近的研究还表明,部分与精神分裂症有关 的基因变异会影响认知能力。进一步研究这些基因对认知功能的影响将有助于了解遗传因素对精神分 裂症认知功能障碍的作用。本综述旨在探讨 CSMD1(CUB and SUSHI multiple domains-1)基因多态性与 精神分裂症及其认知功能损害关系的研究进展。
关键词:  多态性,单核苷酸  精神分裂症  认知损害  CSMD1 基因  综述
DOI:10.3969/j.issn.1009-6574.2019.10.012
基金项目:
Research progress of CSMD1 gene polymorphism and cognitive function in schizophrenia
Xi Zhuo, Liu Wei
()
Abstract:
Schizophrenia is a serious mental illness, most of them are accompanied by cognitive impairment, which places a great burden on patients, families and society. Schizophrenia has a high heritable rate. In the past decade, many genetic variants associated with schizophrenia have been discovered, leading to a better understanding of the complexity of its genetic structure. Recent studies have also shown that genetic variants associated with schizophrenia affect cognitive ability. Further study on the effect of these genes on cognitive function will help us to understand the effect of genetic factors on cognitive dysfunction in schizophrenia. The purpose of this study was to investigate the relationship between CUB and SUSHI multiple domains-1 (CSMD1) gene polymorphism and schizophrenia and its cognitive impairment.
Key words:  Polymorphism, single nucleotide  Schizophrenia  Cognitive impairment  CSMD1 gene  Review

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