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多模态核磁共振在阿尔茨海默病临床研究中的应用 进展
张乃源李绪领张文杰谭亚芳关思奇
0
()
摘要:
阿尔茨海默病(AD)是一种常见的以进行性认知功能障碍为特点的神经变性疾病。其发 病率高且预后差,给社会和家庭带来沉重负担。因此,对于有风险但尚未显示痴呆症状的受试者进行 早期识别、早期干预具有关键意义,而磁共振成像(MRI)将在这方面发挥至关重要的作用。近年来,已 经提出了应用不同类型 MRI 特征进行 AD 转换预测的一些机器学习方法。多模态 MRI 在 AD 诊断中占 有越来越重要的角色。现就 AD 临床多模态影像的研究进展进行综述。
关键词:  阿尔茨海默病  多模态核磁共振  磁共振波谱成像  磁共振弥散张量成像  静息 态功能磁共振成像  综述
DOI:10.3969/j.issn.1009-6574.2019.10.013
基金项目:黑龙江省自然科学基金项目(LC2018036)
Application progress of multimodal MRI in clinical research of Alzheimer disease
Zhang Naiyuan, Li Xuling, Zhang Wenjie, Tan Yafang, Guan Siqi
()
Abstract:
Alzheimer disease (AD) is a common neurodegenerative disease characterized by progressive cognitive impairment. Its high incidence and poor prognosis place a heavy burden on society and families. Therefore, early identification and early intervention of subjects who are at risk but have not shown symptoms is of critical significance, and magnetic resonance imaging (MRI) will play a vital role in this regard. In recent years, some machine learning (ML) methods have been proposed to apply different types of MRI features for AD conversion prediction. Multimodal MRI plays an increasingly important role in the diagnosis of AD. The research progress of AD clinical multimodal imaging is reviewed.
Key words:  Alzheimer disease  Multimodal nuclear magnetic resonance  Magnetic resonance spectroscopy  Magnetic resonance diffusion tensor imaging  Resting state functional magnetic resonance imaging  Review

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