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长链非编码RNA在阿尔茨海默病中的研究进展
刘瑞雪
0
()
摘要:
阿尔茨海默病(AD)属于慢性神经退行性疾病,是引起老年痴呆的主要病因。AD 发病机 制复杂,临床预后极差。长链非编码 RNAs(lncRNAs)是一类不能编码蛋白,通过转录及转录后水平调 节基因的表达,参与了癌症、神经系统、心血管系统以及衰老等病理生理过程。lncRNAs 与 AD 的发生 发展相关在 1992 年首次提出之后,不同 lncRNAs 在 AD 中的作用受到广泛关注。现对近年来 lncRNAs 与 AD 的相关研究进行概述,以期为 AD 的防治提供新思路。
关键词:  阿尔茨海默病  长链非编码 RNAs  表观遗传  综述
DOI:10.3969/j.issn.1009-6574.2020.01.011
基金项目:
Implication of lncRNAs in Alzheimer disease: unraveling novel therapeutic targets
Liu Ruixue
()
Abstract:
Alzheimer disease (AD), a chronic neurodegenerative disorder, is the main cause of dementia. Various factors contribute to AD with poor clinical prognosis. LncRNAs, a kind of non-coding intergenic RNA, are involved in various pathophysiologic processes, such as cancer, neural system disease, cardiovascular disease and aging via transcriptional and post-transcriptional mechanisms. The relationship between lncRNAs and the development of AD was first raised in 1992, and the role of different lncRNAs in AD has received extensive attention. This paper summarizes the studies regarding lncRNAs and AD during last decades and hope to get novel insights into prevention and treatment of AD.
Key words:  Alzheimer disease  LncRNAs  Epigenetic inheritance  Review

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