| 摘要: |
| 目的 评价计算机辅助认知矫正对精神分裂症患者的疗效。方法 检索 PubMed、Web of
Science、Cochrane library、中国学术期刊全文数据库、维普中国科技期刊数据库、万方数据医药期刊库
等资源，收集计算机辅助认知矫正对精神分裂症患者康复疗效的随机对照试验，检索时限均为建库至
2020 年 9 月。采用 RavMan 5.3 软件进行统计处理。结果 共纳入文献 18 篇。Meta 分析显示，计算机辅
助认知矫正能缓解精神分裂症患者的精神病性症状（阳性症状 95%CI：-2.34～-0.03，P=0.04；阴性症状
95%CI：-2.98～-1.97，P＜ 0.01；一般精神病性症状 95%CI：-2.07～-1.25，P＜ 0.01；整体症状 95%CI：
-6.59～-0.86，P=0.01），提高患者生活质量与社会功能（生活质量：95%CI：0.15～1.35，P=0.01；社会功能
95%CI：0.20～1.37，P＜ 0.01），但在改善人际关系和工作等方面的疗效，与对照组比较，差异均无统计
学意义（人际关系 95%CI：-0.25～0.81，P=0.30；工作 95%CI：-0.62～0.18，P=0.28）。结论 计算机辅助
认知矫正对缓解精神分裂症患者的精神病性症状、提高生活质量、增强社会功能有积极疗效，但对人际
关系与工作等的具体疗效仍需进一步研究。 |
| 关键词: 精神分裂症 计算机辅助认知矫正 症状 生活质量 社会功能 |
| DOI：10.3969/j.issn.1009-6574.2020.12.005 |
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| 基金项目: |
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| Meta-analysis of rehabilitation effects of computerized cognitive remediation therapy on patients with schizophrenia |
| Wang Xiaoxiao， Cao Xiang， Zhang Yanhong， Qian Ruilian |
| () |
| Abstract: |
| Objective To evaluate the effects of computerized-assisted cognitive remediation therapy
on patients with schizophrenia. Methods Randomized controlled trials （RCT） on computerized-assisted
cognitive remediation therapy in the rehabilitation of patients with schizophrenia were searched for from
databases such as PubMed， Web of Science， Cochrane Library， China academic journal full text database， VIP
China Science and technology journal database， Wanfang Data medical journal database and other resources，
with a time limit from establishment of the database to September 2020. Data were analyzed with RevMan 5.3
software. Results A total of 18 RCTs were included. The results of meta-analysis showed that computerizedassisted cognitive remediation therapy significantly relieved the symptoms ［positive symptoms： 95%CI（-2.34-
-0.03），P=0.04； negative symptoms： 95%CI（-2.98--1.97），P ＜ 0.01； general psychotic symptoms： 95%CI
（-2.07--1.25），P＜ 0.01； overall symptoms： 95%CI（-6.59--0.86），P=0.01］， also improved quality of life and
social function ［quality of life： 95%CI（0.15-1.35），P=0.01； social function： 95%CI（0.20-1.37），P=0.009］.
However， the results of enhancing interpersonal relationship and working ability were not statistically
significant ［interpersonal relationship： 95%CI（-0.25-0.81），P=0.30； working ability： 95%CI（-0.62-0.18），
P=0.28］. Conclusions Computerized-assisted cognitive remediation therapy has positive effects on relieving
the psychiatric symptoms， improving the quality of life， and enhancing social functions on patients with
schizophrenia， but the effects on interpersonal relationships and working ability still need further study. |
| Key words: Schizophrenia Computerized-assisted cognitive remediation therapy Symptoms Quality of life Social function |
