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炎症反应与急性缺血性脑卒中静脉溶栓后 出血转化的研究进展
吴月殷梅
0
()
摘要:
急性缺血性脑卒中是卒中最常见的形式之一,目前其主要的治疗方式是再灌注治疗,包 括静脉溶栓治疗和血管内治疗。急性缺血性卒中发病时间 6 h 内给予静脉溶栓可改善预后,然而静脉溶 栓同时也存在出血转化的风险,可能对患者早期神经功能改善和远期预后产生不利影响。目前的研究 认为,炎症反应主要参与急性缺血性脑卒中患者静脉溶栓后出血转化的生理病理机制。现对炎症反应 与静脉溶栓后出血转化的相关性风险预测因素进行综述,旨在为溶栓后出血转化的早期识别和预防提 供依据。
关键词:  急性缺血性脑卒中  静脉溶栓  出血转化  炎症因子  预测
DOI:10.3969/j.issn.1009-6574.2020.12.010
基金项目:
Advances in the study of inflammatory reaction and hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke
Wu Yue, Yin Mei
()
Abstract:
As one of the most common forms of stroke, acute ischemic stroke is currently treated by reperfusion, including intravenous thrombolytic therapy and intravascular therapy. Intravenous thrombolysis within 6 hours after the onset of acute ischemic stroke can improve the prognosis. However, intravenous thrombolysis also has the risk of hemorrhagic transformation, which may adversely affect the early improvement of neurological function and long-term prognosis of patients. Current studies suggest that inflammatory reaction is mainly involved in the physiological and pathological mechanism of hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke. In this paper, the risk predictors of the correlation between inflammatory response and hemorrhagic transformation after intravenous thrombolysis are reviewed in order to provide evidence for the early identification and prevention of hemorrhagic transformation after intravenous thrombolysis.
Key words:  Acute ischemic cerebral stroke  Intravenous thrombdysis  Hemorrhagic transformation  Inflammatory factor  Forecast

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