| 摘要: |
| 双相障碍（BD）是一组高异质性疾病，多成年早期发病，但病理学机制还不十分清楚。近
年来，有证据支持“神经发育异常”假说可能参与了部分 BD 尤其是早发伴有精神病性症状患者的发病，
为其病理学机制研究提供了新方向。现从围生期危险因素、早期临床特征、神经心理学、脑影像学和基
因组等方面对相关证据进行综述。 |
| 关键词: 双相障碍 神经发育假说 病理学机制 综述 |
| DOI：10.3969/j.issn.1009-6574.2020.12.011 |
|
| 基金项目:河北省高层次人才资助项目（A2016002087）；河北省科学技术研究与发展计划项目
（152777223）；石家庄市科学技术研究与发展指导计划（171462273） |
|
| Advances in "neurodevelopmental abnormality" hypothesis in bipolar disorder |
| Sun Zhigang，
Xue Man， Gu Jianfeng， Li Sushui |
| () |
| Abstract: |
| Bipolar disorder （BD） is a group of highly heterogeneous diseases， mostly occurring in
early adulthood， but the pathological mechanism is still unclear. In recent years， there is evidence to support
the hypothesis that "neurodevelopmental abnormality" may be involved in the pathogenesis of some BD
patients， especially those with early-onset psychotic symptoms， providing a new direction for the study of its
pathological mechanism. This paper reviews the evidence from perinatal risk factors， early clinical features，
neuropsychology， brain imaging and genome. |
| Key words: Bipolar disorder Neurodevelopmental hypothesis Pathological mechanism Review |
