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环磷酸腺苷反应元件结合蛋白与认知功能障碍相关 疾病研究进展
李敬宇燕兴梅邱颐
0
()
摘要:
环磷酸腺苷反应元件结合蛋白(CREB)是一种重要的核内转录因子,参与多种信号通路, CREB 表达异常可参与认知功能障碍疾病。术后认知功能障碍、血管性痴呆和癫痫是 3 种典型认知功能 障碍相关疾病。现就对 CREB 和其形成的信号通路在这三种疾病中的作用进行总结。
关键词:  认知障碍  痴呆,血管性  癫痫  环磷酸腺苷反应元件结合蛋白  综述
DOI:10.3969/j.issn.1009-6574.2020.03.009
基金项目:国家自然科学基金项目(81560192)
Research progress in CREB and cognitive dysfunction diseases
Li Jingyu, Yan Xingmei, Qiu Yi
()
Abstract:
cAMP-responsive element binding protein (CREB) is an important nuclear transcriptional factor, which is involved in a variety of signal pathways. Abnormal expression of CREB may be involved in cognitive disorders. Postoperative cognitive dysfunction, vascular dementia and epilepsy are three typical cognitive impairment related diseases. This review summarizes the role of CREB and its signal pathway in these three diseases.
Key words:  Cognition disorders  Dementia, vascular  Epilepsy  cAMP-responsive element binding protein  Review

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