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醒后卒中的研究进展
崔鑫陈丹张蓓李亚军
0
()
摘要:
醒后卒中(WUS)是指入睡时无神经系统症状,觉醒后患者本人或目击者发现有卒中症状, 占急性缺血性脑卒中的 14.3%~29.6%。由于发病时间的不确定,通常不适用于急性缺血性卒中时间窗 内特殊治疗。近年来,随着多模式CT及磁共振成像对缺血性卒中梗死灶及缺血半暗带识别的技术发展, 越来越多的证据表明静脉溶栓、机械取栓等治疗方案使 WUS 患者更好地获益。现对 WUS 的病理生理 机制、危险因素、临床及影像学特征、治疗方案的最新进展作一综述
关键词:  醒后卒中  昼夜节律  多模式 CT  静脉溶栓  机械取栓  综述
DOI:10.3969/j.issn.1009-6574.2020.04.012
基金项目:
Research progress in wake-up stroke
Cui Xin, Chen Dan, Zhang Bei, Li Yajun
()
Abstract:
Wake-up stroke (WUS) refers to the stroke which do not have neurological system symptoms during sleep, but is found after waking up, by patients or witnesses. It takes 14.3%-29.6% proportion of acute ischemic stroke. Because of the uncertainty of the onset time, it is usually not suitable for the specific treatment of acute ischemic stroke in time window. In recent years, with the development of multimodality CT (MCT) and magnetic resonance imaging (MRI) in the recognition of ischemic stroke infarct and ischemic penumbra, there is increasing evidence that intravenous thrombolysis, mechanical thrombolysis and other treatment regimens benefit WUS patients better. A review of the pathophysiological mechanism, risk factors, clinical and imaging characteristics, and the latest development of treatment plan of WUS is presented in this paper.
Key words:  Wake-up stroke  Circadian rhythm  Multimodality CT  intravenous thrombolysis  Mechanical thrombectomy  Review

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