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低氧对大脑执行功能影响的任务态功能磁共振成像 研究
禹智波吕艳冰陈许波彭佳宋凌恒兰晓川李福锁李锦青
0
()
摘要:
目的 探讨低氧状态对大脑执行功能的影响。方法 采用阻氧面罩模拟海拔5 000 m环境 氧气状态,纳入解放军陆军第九五八医院2019 年1 月至2020 年4 月军人陪护志愿者40 名,对研究对象 低氧状态前后进行计算机神经心理学测试以评估认知和执行功能(包括整体神经认知指数、复合记忆、 言语记忆、视觉记忆、精神运动速度、反应时间、复合注意、认知灵活性、处理速度、执行功能、简单注意 和精细运动速度等),每个中枢神经系统测试包括词语记忆、视觉图片记忆、手指连续敲击、数字符号编 码、Stroop 测试、连续性能和移位注意测试7 个部分。采取Go/NoGo 范式任务功能磁共振成像(MRI)数 据,采用局部一致性分析法分析研究受试者常氧状态和低氧状态时大脑执行功能的差异。结果 低氧 状态时,受试者神经认知领域评分较常氧状态时均显著降低,其中整体神经认知指数[(95.54±6.59)分 比(100.75±7.08)分]、复合记忆[(92.15±10.23)分比(98.35±8.16)分]、言语记忆[(92.56±9.51)分比 (99.46±6.42)分]、精神运动速度[(109.63±6.64)分比(119.36±16.78)分]、反应时间[(89.87±9.09)分比 (98.63±6.37)分]、处理速度[(112.67±14.35)分比(131.78±14.53)分]、执行功能[(106.43±11.75)分比 (115.33±10.82)分]差异均有统计学意义(均P< 0.05)。低氧状态下,受试者Go/NoGo 任务的反应正确 率较常氧状态时降低[(83.85±7.74)% 比(89.9±6.01)%,t=-4.27,P < 0.01],按键反应时间较常氧状态 时增加[(1 049.28±171.28)ms 比(957.08±178.14)ms;t=2.32,P=0.025]。左侧颞下回(0.516±0.045)、颞 中回(0.534±0.064)、海马旁回(0.519±0.046)和右侧颞叶下回(0.549±0.056)局部一致性值较常氧状态 时增高;左侧颞上回(0.411±0.048)、额下回(0.478±0.049)、角回(0.503±0.063)、顶上小叶(0.512±0.070) 和右侧梭状回(0.461±0.044)、颞上回(0.455±0.046)、前扣带回(0.494±0.049)局部一致性值较常氧状态 时降低,差异均有统计学意义(均P< 0.05)。结论 低氧状态影响大脑的多个脑区的功能,这些区域与 执行控制相关,导致大脑的作业绩效下降。
关键词:  缺氧  执行功能  磁共振成像  局部一致性
DOI:10.3969/j.issn.1009-6574.2020.07.003
基金项目:中国人民解放军陆军后勤科研面上项目(CLJ17J018)
A task-state functional magnetic resonance imaging study of the effects of hypoxia on brain executivefunction
Yu Zhibo, Lyu Yanbing, Chen Xubo, Peng Jia, Song Lingheng, Lan Xiaochuan, Li Fusuo, Li Jinqing
()
Abstract:
Objective To investigate the effect of hypoxia on executive function of brain. Methods Oxygenblocking masks were used to simulate the oxygen state at an altitude of 5 000 meters. From January 2019 to April 2020, 40 military accompanying volunteers from the 958 Hospital of PLA were included in the study. Computer neuropsychological tests were conducted before and after hypoxia to evaluate cognitive and executive functions (including global neurocognitive index, compound memory, verbal memory, visual memory, psychomotor speed, reaction time, compound attention, cognitive flexibility, processing speed, executive function, simple attention and fine motor speed, and so on). Each central nervous system test includes seven parts: word memory, visual picture memory, finger continuous tapping, digit symbol coding, Stroop test, continuous performance and shift attention test. The Go / NoGo paradigm task functional magnetic resonance imaging (MRI) data was used. Local consistency analysis method was used to analyze the differences of brain executive function between normoxia and hypoxia. Results Under hypoxic conditions, the scores of neurocognitive domain were significantly lower than those under normoxic condition, including overall neurocognitive index [(95.54±6.59) vs( 100.75±7.08)], complex memory[ (92.15±10.23) vs( 98.35±8.16)], verbal memory [(92.56±9.51) vs( 99.46±6.42)], psychomotor speed[ (109.63±6.64) vs( 119.36±16.78)], reaction time [(89.87±9.09) vs( 98.63±6.37)], processing speed[ (112.67±14.35) vs( 131.78±14.53)], executive function [(106.43±11.75) vs( 115.33±10.82)]. The differences were statistically significant( all P < 0.05). The response accuracy rate of Go/NoGo task under hypoxic condition was lower than that under normoxic condition [(83.85±7.74)% vs( 89.9±6.01)%, t=-4.27,P < 0.01], and the reaction time of keys was increased [(1 049.28±171.28) ms vs( 957.08±178.14) ms; t=2.32,P=0.025]. The local consistency values of left inferior temporal gyrus( 0.516±0.045), middle temporal gyrus( 0.534±0.064), parahippocampal gyrus( 0.519±0.046) and right inferior temporal gyrus( 0.549±0.056) were higher than those under normoxic condition; The local consistency values of left superior temporal gyrus( 0.411±0.048), inferior frontal gyrus( 0.478±0.049), angular gyrus( 0.503±0.063), superior parietal lobule( 0.512±0.070), right fusiform gyrus( 0.461±0.044), superior temporal gyrus( 0.455±0.046), and anterior cingulate gyrus( 0.494±0.049) were lower than those under normoxic condition. The differences were statistically significant( all P<0.05). Conclusions Hypoxia affects the function of multiple brain regions, which are related to executive control, resulting in decrease of brain tasks performance.
Key words:  Hypoxia  Executive function  Magnetic resonance imaging  Local consistency

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