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布南色林透皮贴剂的研究现状
翟倩丰雷
0
()
摘要:
尽管目前有大量抗精神病药物用于精神障碍的治疗,然而由于药物的不良反应以及给药 方式等因素,导致患者治疗的依从性差。透皮给药的方式能够减少肝脏首过效应,避免胃肠道刺激,血 药浓度更加稳定,且给药方便,大大增加了患者的依从性。布南色林属于第二代抗精神病药物,能够有 效地改善精神分裂症的阳性、阴性和认知症状,目前已经完成了3 期临床试验,有着较高的有效性和安 全性,在精神障碍的药物治疗中有着巨大的前景。现就布南色林透皮贴剂的研究现状作进一步综述。
关键词:  抗精神病药  布南色林透皮贴剂  有效性  安全性  综述
DOI:10.3969/j.issn.1009-6574.2020.11.015
基金项目:国家科技重大专项重大新药创制(2018ZX09734-005);首都卫生发展科研专项(2018-1-2121)
Research status of blonanserin transdermal patch
Zhai Qian, Feng Lei
()
Abstract:
Although a large number of antipsychotics are used for the treatment of mental disorders currently, the compliance of patients is poor due to the adverse drug reactions, administration methods, and other factors. Transdermal drug delivery can reduce the first-pass effect of liver, avoid gastrointestinal irritation, make the blood concentration more stable, and is convenient, because of which the compliance of patients is greatly increased. Blonanserin is a second generation antipsychotic drug, which can improve the positive, negative and cognitive symptoms of schizophrenia effectively. Blonanserin transdermal patch has completed phase 3 clinical trials, with high efficacy and safety,and there are great prospects for drug treatment of mental disorders. In this paper, the research status of blonanserin transdermal patch is reviewed.
Key words:  Antipsychotic agents  Blonanserin transdermal patch  Efficacy  Safety  Review

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