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孤独症谱系障碍疼痛敏感程度及机制的研究进展
刘思彤于佳弘华然李齐李想范莉莉施梅
0
()
摘要:
孤独症谱系障碍(autism spectrum disorders,ASD)是一种起始于婴幼儿时期的神经发育障 碍性疾病,除社会交往障碍、认知缺失、重复刻板行为等核心症状外,还存在明显的多感官异常,其中 ASD患者疼痛异常会做出重复性的自我伤害行为,这种障碍不仅给患者也对其家庭造成了较为严重的 伤害,引起家庭和社会的广泛关注。对患儿疼痛敏感程度及影响疼痛敏感性的原理及机制进行深入研 究,不仅可以减轻患儿的痛苦体验,也能够为ASD患儿治疗方面提供新的思路。现对近年来在ASD 人 群中流行病学、临床实验、遗传学、影像学及ASD 动物模型的痛觉敏感程度及可能机制的研究进行综述, 在今后的研究中,可以尝试探索优化干预方案,为进一步推广临床提供理论依据。
关键词:  孤独症谱系障碍  疼痛敏感程度  机制  综述
DOI:10.3969/j.issn.1009-6574.2021.01.010
基金项目:黑龙江省卫生计生委科研课题(2017-166);黑龙江省省属高校基本科研业务费科研项目 (2018-KYYWF-0440)
Advances in autism spectram disorders pain sensitivity and mechanism
Liu Sitong, Yu Jiahong, Hua Ran, Li Qi, Li Xiang, Fan Lili, Shi Mei
()
Abstract:
Autism spectrum disorders( ASD) is a neurodevelopmental disorder starting in infancy. In addition to the core symptoms of social interaction disorder, cognitive impairment and repetitive stereotyped behavior, there are also obvious multi-sensory abnormalities. ASD patients with abnormal pain will make repetitive self-injurious behavior, which not only causes serious harm to patients but also their families, causing widespread concern of families and society. Further study on the pain sensitivity of children and the principle and mechanism of pain sensitivity can not only reduce the pain experience of children, but also provide new ideas for the treatment of children with ASD. This paper reviewed the recent studies on the epidemiology, clinical trials, genetics, imaging and the pain sensitivity of ASD animal models. The future study could focus on the optimal intervention scheme, and provide theoretical basis for further clinical promotion.
Key words:  Autism spectrum disorders  Pain sensitivity  Mechanism  Review

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