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拷贝数变异及单核苷酸变异基因型自闭症动物模型 研究进展
罗舒心刘仲钰钟振国梁明坤钟静
0
()
摘要:
自闭症的发病率逐年升高,因其致病原因的复杂性,使得自闭症的研究成为难点。研究 发现遗传因素约占自闭症发病率的50%,然而能有效反映病因的动物模型却少之又少,现综述基于拷 贝数变异(CNV)和单核苷酸变异(SNVs)建立的基因型自闭症动物模型,作为以后了解自闭症机制的新 高级模型工具
关键词:  自闭症  基因  疾病模型,动物  综述
DOI:10.3969/j.issn.1009-6574.2021.01.011
基金项目:广西自然科学基金青年科学基金项目(2018GXNSFBA138008)
Research progress of autism animal models with CNVs and SNVs genotypes
Luo Shuxing, Liu Zhongyu, Zhong Zhenguo, Liang Mingkun, Zhong Jing
()
Abstract:
The incidence rate of autism has been increasing year by year. Because of the complexity of its pathogenic causes, the study of autism has become difficult. Studies show that genetic factors account for 50% of the incidence rate of autism. However, there were few animal models that could effectively reflect the etiology. This article reviews the animal models of genotype autism based on copy number variation( CNV) and single nucleotide variation( SNVs), as a new advanced model tool to understand the mechanism of autism in the future.
Key words:  Autism  Gene  Disease models, animal  Review

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