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应激在抑郁障碍发生中的作用
程洋英林邬素萍
0
()
摘要:
抑郁障碍现已成为世界范围内导致死亡和残疾的主要原因之一,其发病机制目前尚无确 切定论。近年来,越来越多的学者认为,抑郁障碍的发生可能与应激反应有关。应激反应会引起神经 可塑性改变、下丘脑-垂体-肾上腺轴异常以及神经递质变化,造成大脑结构和功能的紊乱,最终导致 抑郁障碍的发生。
关键词:  抑郁障碍  应激  神经可塑性  HPA轴  综述
DOI:10.3969/j.issn.1009-6574.2021.01.012
基金项目:广西自然科学基金青年科学基金项目(2018GXNSFBA138008)
Role of stress in depression disorder
Cheng Yangyinglin, Wu Suping
()
Abstract:
Depressive disorder has become one of the main causes of death and disability in the world, and its pathogenesis has not yet been determined. In recent years, more and more scholars believe that the occurrence of depression may be related to stress response. Stress response may cause changes in plasticity of nerve cells, abnormal regulation of hypothalamus pituitary adrenal axis and changes of neurotransmitter secretion, resulting in brain structure and function disorders, and eventually lead to the occurrence of depression.
Key words:  Depression disorders  Stress  Neural plasticity  Hypothalamus pituitary adrenal axis( HPA axis)  Review

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