| 摘要: |
| 阿尔茨海默病（AD）是一类好发于老年人的退行性疾病，常表现为记忆障碍和行为失常，
严重危害老年人的身心健康与生活质量。攻克 AD 已经成为世界性的热点问题。目前的研究表明，神
经性炎性免疫反应在 AD 发病机制中发挥着重要的作用。本文就神经炎症与免疫因素对 AD 发病机制
的作用研究进行综述，以期为预防和治疗 AD 提供新线索。 |
| 关键词: 阿尔茨海默病 神经炎症 小胶质细胞 星形胶质细胞 综述 |
| DOI：10.3969/j.issn.1009-6574.2022.06.014 |
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| 基金项目: |
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| Research progress of inflammatory immunity in the pathogenesis of Alzheimer disease |
| Chen Fan,Wang Na,He Xiaping |
| () |
| Abstract: |
| Alzheimer disease （AD） is a age-related progressive neurodegenerative disease， which is
clinically manifested as memory impairment and behavioral disorders. It seriously endanger the physical and
mental health and life quality of the elderly worldwide and represent a challenge for the public health. Current
studies have shown that neuroinflammatory immune response plays an important role in the pathogenesis of AD.
This paper reviews the role of neuroinflammation and immune factors in the pathogenesis of AD， in order to
provide new clues for the prevention and treatment of AD. |
| Key words: Alzheimer disease Neuroinflammation Microglia Astrocytes Review |
